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PTEN Suppresses Tumorigenesis by Directly Dephosphorylating Akt

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Date 2021 Jul 12
PMID 34248141
Citations 12
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References
1.
Manning B, Toker A . AKT/PKB Signaling: Navigating the Network. Cell. 2017; 169(3):381-405. PMC: 5546324. DOI: 10.1016/j.cell.2017.04.001. View

2.
Zoncu R, Efeyan A, Sabatini D . mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol. 2010; 12(1):21-35. PMC: 3390257. DOI: 10.1038/nrm3025. View

3.
Song M, Salmena L, Pandolfi P . The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol. 2012; 13(5):283-96. DOI: 10.1038/nrm3330. View

4.
Klarlund J, Guilherme A, Holik J, Virbasius J, Chawla A, Czech M . Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science. 1997; 275(5308):1927-30. DOI: 10.1126/science.275.5308.1927. View

5.
Lindsay Y, McCoull D, Davidson L, Leslie N, Fairservice A, Gray A . Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression. J Cell Sci. 2006; 119(Pt 24):5160-8. DOI: 10.1242/jcs.000133. View