Aptamers Isolated Against Mosquito-borne Pathogens

Overview

Journal World J Microbiol Biotechnol

Publisher Springer

Specialties Biotechnology
Microbiology

Date 2021 Jul 9

PMID 34240263

Citations 1

Authors

Tholasi Nadhan Navien

Tzi Shien Yeoh

Andrew Anna

Thean-Hock Tang

Marimuthu Citartan

Affiliations

Soon will be listed here.

Abstract

Mosquito-borne diseases are a major threat to public health. The shortcomings of diagnostic tools, especially those that are antibody-based, have been blamed in part for the rising annual morbidity and mortality caused by these diseases. Antibodies harbor a number of disadvantages that can be clearly addressed by aptamers as the more promising molecular recognition elements. Aptamers are defined as single-stranded DNA or RNA oligonucleotides generated by SELEX that exhibit high binding affinity and specificity against a wide variety of target molecules based on their unique structural conformations. A number of aptamers were developed against mosquito-borne pathogens such as Dengue virus, Zika virus, Chikungunya virus, Plasmodium parasite, Francisella tularensis, Japanese encephalitis virus, Venezuelan equine encephalitis virus, Rift Valley fever virus and Yellow fever virus. Intrigued by these achievements, we carry out a comprehensive overview of the aptamers developed against these mosquito-borne infectious agents. Characteristics of the aptamers and their roles in diagnostic, therapeutic as well as other applications are emphasized.

Citing Articles

Aptamers: A Cutting-Edge Approach for Gram-Negative Bacterial Pathogen Identification.

Cordova-Espinoza M, Gonzalez-Vazquez R, Barron-Fattel R, Gonzalez-Vazquez R, Antonio Vargas-Hernandez M, Albores-Mendez E Int J Mol Sci. 2024; 25(2).

PMID: 38279257 PMC: 10817072. DOI: 10.3390/ijms25021257.

References

Anderson Jr G, Saluzzo J, Ksiazek T, Smith J, Ennis W, Thureen D . Comparison of in vitro and in vivo systems for propagation of Rift Valley fever virus from clinical specimens. Res Virol. 1989; 140(2):129-38. DOI: 10.1016/s0923-2516(89)80090-1. View

Ashley E, Phyo A, Woodrow C . Malaria. Lancet. 2018; 391(10130):1608-1621. DOI: 10.1016/S0140-6736(18)30324-6. View

Backman S, Naslund J, Forsman M, Thelaus J . Transmission of tularemia from a water source by transstadial maintenance in a mosquito vector. Sci Rep. 2015; 5:7793. PMC: 4302321. DOI: 10.1038/srep07793. View

Balinsky C, Schmeisser H, Ganesan S, Singh K, Pierson T, Zoon K . Nucleolin interacts with the dengue virus capsid protein and plays a role in formation of infectious virus particles. J Virol. 2013; 87(24):13094-106. PMC: 3838225. DOI: 10.1128/JVI.00704-13. View

Barfod A, Persson T, Lindh J . In vitro selection of RNA aptamers against a conserved region of the Plasmodium falciparum erythrocyte membrane protein 1. Parasitol Res. 2009; 105(6):1557-66. PMC: 2764096. DOI: 10.1007/s00436-009-1583-x. View

Barzon L, Palu G . Recent developments in vaccines and biological therapies against Japanese encephalitis virus. Expert Opin Biol Ther. 2018; 18(8):851-864. DOI: 10.1080/14712598.2018.1499721. View

Basso C, Crulhas B, Magro M, Vianello F, Pedrosa V . A new immunoassay of hybrid nanomater conjugated to aptamers for the detection of dengue virus. Talanta. 2019; 197:482-490. DOI: 10.1016/j.talanta.2019.01.058. View

Bharucha T, Shearer F, Vongsouvath M, Mayxay M, de Lamballerie X, Newton P . A need to raise the bar - A systematic review of temporal trends in diagnostics for Japanese encephalitis virus infection, and perspectives for future research. Int J Infect Dis. 2020; 95:444-456. PMC: 7294235. DOI: 10.1016/j.ijid.2020.03.039. View

Bird B, Bawiec D, Ksiazek T, Shoemaker T, Nichol S . Highly sensitive and broadly reactive quantitative reverse transcription-PCR assay for high-throughput detection of Rift Valley fever virus. J Clin Microbiol. 2007; 45(11):3506-13. PMC: 2168471. DOI: 10.1128/JCM.00936-07. View

10.

Bird B, Ksiazek T, Nichol S, Maclachlan N . Rift Valley fever virus. J Am Vet Med Assoc. 2009; 234(7):883-93. DOI: 10.2460/javma.234.7.883. View

11.

Bowen G, Calisher C . Virological and serological studies of Venezuelan equine encephalomyelitis in humans. J Clin Microbiol. 1976; 4(1):22-7. PMC: 274383. DOI: 10.1128/jcm.4.1.22-27.1976. View

12.

Breaker R . DNA aptamers and DNA enzymes. Curr Opin Chem Biol. 1997; 1(1):26-31. DOI: 10.1016/s1367-5931(97)80105-6. View

13.

Butcher S, Pyle A . The molecular interactions that stabilize RNA tertiary structure: RNA motifs, patterns, and networks. Acc Chem Res. 2011; 44(12):1302-11. DOI: 10.1021/ar200098t. View

14.

Campbell G, Hills S, Fischer M, Jacobson J, Hoke C, Hombach J . Estimated global incidence of Japanese encephalitis: a systematic review. Bull World Health Organ. 2011; 89(10):766-74, 774A-774E. PMC: 3209971. DOI: 10.2471/BLT.10.085233. View

15.

Carrara A, Gonzales G, Ferro C, Tamayo M, Aronson J, Paessler S . Venezuelan equine encephalitis virus infection of spiny rats. Emerg Infect Dis. 2005; 11(5):663-9. PMC: 3320368. DOI: 10.3201/eid1105.041251. View

16.

Carrara A, Coffey L, Aguilar P, Moncayo A, Travassos da Rosa A, Nunes M . Venezuelan equine encephalitis virus infection of cotton rats. Emerg Infect Dis. 2007; 13(8):1158-65. PMC: 2828070. DOI: 10.3201/eid1308.061157. View

17.

Chen Y, Liu L . Modern methods for delivery of drugs across the blood-brain barrier. Adv Drug Deliv Rev. 2011; 64(7):640-65. DOI: 10.1016/j.addr.2011.11.010. View

18.

Cheung Y, Kwok J, Law A, Watt R, Kotaka M, Tanner J . Structural basis for discriminatory recognition of Plasmodium lactate dehydrogenase by a DNA aptamer. Proc Natl Acad Sci U S A. 2013; 110(40):15967-72. PMC: 3791781. DOI: 10.1073/pnas.1309538110. View

19.

Cheung Y, Rothlisberger P, Mechaly A, Weber P, Levi-Acobas F, Lo Y . Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker. Proc Natl Acad Sci U S A. 2020; 117(29):16790-16798. PMC: 7382308. DOI: 10.1073/pnas.2003267117. View

20.

Chiang C, Beljanski V, Yin K, Olagnier D, Ben Yebdri F, Steel C . Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists. J Virol. 2015; 89(15):8011-25. PMC: 4505665. DOI: 10.1128/JVI.00845-15. View