The Present and Future of Mitochondrial-Based Therapeutics for Eye Disease

Overview

Journal Transl Vis Sci Technol

Specialties Biomedical Engineering
Ophthalmology

Date 2021 Jul 7

PMID 34232272

Citations 5

Authors

Marco H Ji

Alexander Kreymerman

Kinsley Belle

Benjamin K Ghiam

Stephanie R Muscat

Vinit B Mahajan

Gregory M Enns

Mark Mercola

Edward H Wood

Affiliations

Soon will be listed here.

Abstract

Mitochondria are viable therapeutic targets for a broad spectrum of ocular diseases.

Citing Articles

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Dysfunctional Autophagy, Proteostasis, and Mitochondria as a Prelude to Age-Related Macular Degeneration.

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References

Merrill P, Clark W, Banker A, Fardeau C, Franco P, LeHoang P . Efficacy and Safety of Intravitreal Sirolimus for Noninfectious Uveitis of the Posterior Segment: Results from the Sirolimus Study Assessing Double-Masked Uveitis Treatment (SAKURA) Program. Ophthalmology. 2020; 127(10):1405-1415. DOI: 10.1016/j.ophtha.2020.03.033. View

Cohen J, Scott R, Schimmel T, Levron J, Willadsen S . Birth of infant after transfer of anucleate donor oocyte cytoplasm into recipient eggs. Lancet. 1997; 350(9072):186-7. DOI: 10.1016/S0140-6736(05)62353-7. View

King R, Kent K, Bomser J . Resveratrol reduces oxidation and proliferation of human retinal pigment epithelial cells via extracellular signal-regulated kinase inhibition. Chem Biol Interact. 2005; 151(2):143-9. DOI: 10.1016/j.cbi.2004.11.003. View

Zhang J, Liu H, Luo S, Lu Z, Chavez-Badiola A, Liu Z . Live birth derived from oocyte spindle transfer to prevent mitochondrial disease. Reprod Biomed Online. 2017; 34(4):361-368. DOI: 10.1016/j.rbmo.2017.01.013. View

Esposti M, Ngo A, Ghelli A, Benelli B, Carelli V, McLennan H . The interaction of Q analogs, particularly hydroxydecyl benzoquinone (idebenone), with the respiratory complexes of heart mitochondria. Arch Biochem Biophys. 1996; 330(2):395-400. DOI: 10.1006/abbi.1996.0267. View

Manfredi G, Fu J, Ojaimi J, Sadlock J, Kwong J, Guy J . Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus. Nat Genet. 2002; 30(4):394-9. DOI: 10.1038/ng851. View

Moehle E, Shen K, Dillin A . Mitochondrial proteostasis in the context of cellular and organismal health and aging. J Biol Chem. 2018; 294(14):5396-5407. PMC: 6462515. DOI: 10.1074/jbc.TM117.000893. View

Han J, Li Y, Liu X, Zhou T, Sun H, Edwards P . Metformin suppresses retinal angiogenesis and inflammation in vitro and in vivo. PLoS One. 2018; 13(3):e0193031. PMC: 5841739. DOI: 10.1371/journal.pone.0193031. View

Rocha A, Franco A, Krezel A, Rumsey J, Alberti J, Knight W . MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A. Science. 2018; 360(6386):336-341. PMC: 6109362. DOI: 10.1126/science.aao1785. View

10.

Frost L, Mitchell C, Boesze-Battaglia K . Autophagy in the eye: implications for ocular cell health. Exp Eye Res. 2014; 124:56-66. PMC: 4156154. DOI: 10.1016/j.exer.2014.04.010. View

11.

Del Amo E, Rimpela A, Heikkinen E, Kari O, Ramsay E, Lajunen T . Pharmacokinetic aspects of retinal drug delivery. Prog Retin Eye Res. 2016; 57:134-185. DOI: 10.1016/j.preteyeres.2016.12.001. View

12.

Ates O, Alp H, Mumcu U, Azizi S, Cinici E, Kiziltunc A . The effect of L-carnitine treatment on levels of malondialdehyde and glutathione in patients with age related macular degeneration. Eurasian J Med. 2015; 40(1):1-5. PMC: 4261317. View

13.

Artika I . Allotopic expression of mitochondrial genes: Basic strategy and progress. Genes Dis. 2020; 7(4):578-584. PMC: 7729113. DOI: 10.1016/j.gendis.2019.08.001. View

14.

Mok B, de Moraes M, Zeng J, Bosch D, Kotrys A, Raguram A . A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing. Nature. 2020; 583(7817):631-637. PMC: 7381381. DOI: 10.1038/s41586-020-2477-4. View

15.

Miret-Casals L, Sebastian D, Brea J, Rico-Leo E, Palacin M, Fernandez-Salguero P . Identification of New Activators of Mitochondrial Fusion Reveals a Link between Mitochondrial Morphology and Pyrimidine Metabolism. Cell Chem Biol. 2018; 25(3):268-278.e4. DOI: 10.1016/j.chembiol.2017.12.001. View

16.

Payne B, Wilson I, Yu-Wai-Man P, Coxhead J, Deehan D, Horvath R . Universal heteroplasmy of human mitochondrial DNA. Hum Mol Genet. 2012; 22(2):384-90. PMC: 3526165. DOI: 10.1093/hmg/dds435. View

17.

Garrido-Maraver J, Paz M, Cordero M, Bautista-Lorite J, Oropesa-Avila M, de la Mata M . Critical role of AMP-activated protein kinase in the balance between mitophagy and mitochondrial biogenesis in MELAS disease. Biochim Biophys Acta. 2015; 1852(11):2535-53. DOI: 10.1016/j.bbadis.2015.08.027. View

18.

Weiss J, Levy S . Stem Cell Ophthalmology Treatment Study (SCOTS): bone marrow derived stem cells in the treatment of Dominant Optic Atrophy. Stem Cell Investig. 2020; 6:41. PMC: 6987313. DOI: 10.21037/sci.2019.11.01. View

19.

Youle R, Narendra D . Mechanisms of mitophagy. Nat Rev Mol Cell Biol. 2010; 12(1):9-14. PMC: 4780047. DOI: 10.1038/nrm3028. View

20.

Hashimoto M, Bacman S, Peralta S, Falk M, Chomyn A, Chan D . MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases. Mol Ther. 2015; 23(10):1592-9. PMC: 4817924. DOI: 10.1038/mt.2015.126. View