Deletion of CD73 Increases Exercise Power in Mice

Overview

Journal Purinergic Signal

Publisher Springer

Date 2021 Jul 3

PMID 34216353

Citations 5

Authors

Aderbal S Aguiar Jr

Ana Elisa Speck

Paula M Canas

Rodrigo A Cunha

Affiliations

Soon will be listed here.

Abstract

Ecto-5'-nucleotidase or CD73 is the main source of extracellular adenosine involved in the activation of adenosine A receptors, responsible for the ergogenic effects of caffeine. We now investigated the role of CD73 in exercise by comparing female wild-type (WT) and CD73 knockout (KO) mice in a treadmill-graded test to evaluate running power, oxygen uptake (V̇O), and respiratory exchange ratio (RER) - the gold standards characterizing physical performance. Spontaneous locomotion in the open field and submaximal running power and V̇O in the treadmill were similar between CD73-KO and WT mice; V̇Omax also demonstrated equivalent aerobic power, but CD73-KO mice displayed a 43.7 ± 4.2% larger critical power (large effect size, P < 0.05) and 3.8 ± 0.4% increase of maximum RER (small effect size, P < 0.05). Thus, KO of CD73 was ergogenic; i.e., it increased physical performance.

Citing Articles

Adenosine A and dopamine D receptor interaction controls fatigue resistance.

Alves A, Santos N, Santos A, da Panatta G, Speck A, Cunha R Front Pharmacol. 2024; 15:1390187.

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Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress.

Dias L, Pochmann D, Lemos C, Silva H, Real J, Goncalves F ACS Chem Neurosci. 2023; 14(7):1299-1309.

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The striatum drives the ergogenic effects of caffeine.

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CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity.

Simoes A, Goncalves F, Rial D, Ferreira S, Lopes J, Canas P Int J Mol Sci. 2022; 23(21).

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