The Striatum Drives the Ergogenic Effects of Caffeine

Overview

Journal Purinergic Signal

Publisher Springer

Date 2023 Jan 25

PMID 36697868

Authors

Ana Cristina de Bem Alves

Ana Elisa Speck

Hemelin Resende Farias

Leo Meira Martins

Naiara Souza Dos Santos

Gabriela Pannata

Ana Paula Tavares

Jade de Oliveira

Angelo R Tome

Rodrigo A Cunha

Aderbal S Aguiar Jr

Affiliations

Soon will be listed here.

Abstract

Caffeine is one of the main ergogenic resources used in exercise and sports. Previously, we reported the ergogenic mechanism of caffeine through neuronal AR antagonism in the central nervous system [1]. We now demonstrate that the striatum rules the ergogenic effects of caffeine through neuroplasticity changes. Thirty-four Swiss (8-10 weeks, 47 ± 1.5 g) and twenty-four C57BL/6J (8-10 weeks, 23.9 ± 0.4 g) adult male mice were studied behaviorly and electrophysiologically using caffeine and energy metabolism was studied in SH-SY5Y cells. Systemic (15 mg/kg, i.p.) or striatal (bilateral, 15 μg) caffeine was psychostimulant in the open field (p < 0.05) and increased grip efficiency (p < 0.05). Caffeine also shifted long-term depression (LTD) to potentiation (LTP) in striatal slices and increased the mitochondrial mass (p < 0.05) and membrane potential (p < 0.05) in SH-SY5Y dopaminergic cells. Our results demonstrate the role of the striatum in the ergogenic effects of caffeine, with changes in neuroplasticity and mitochondrial metabolism.

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