Exercise Training Enhances Myocardial Mitophagy and Improves Cardiac Function Via Irisin/FNDC5-PINK1/Parkin Pathway in MI Mice

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2021 Jul 2

PMID 34205641

Citations 16

Authors

Hangzhuo Li

Shuguang Qin

Qiaoqin Liang

Yue Xi

Wenyan Bo

Mengxin Cai

Zhenjun Tian

Affiliations

Soon will be listed here.

Abstract

Myocardial infarction is the major cause of death in cardiovascular disease. In vitro and in vivo models are used to find the exercise mode which has the most significant effect on myocardial irisin/FNDC5 expression and illuminate the cardioprotective role and mechanisms of exercise-activated myocardial irisin/FNDC5-PINK1/Parkin-mediated mitophagy in myocardial infarction. The results indicated that expression of irisin/FNDC5 in myocardium could be up-regulated by different types of exercise and skeletal muscle electrical stimulation, which then promotes mitophagy and improves cardiac function and the effect of resistance exercise. Resistance exercise can improve cardiac function by activating the irisin/FNDC5-PINK1/Parkin-LC3/P62 pathway, regulating mitophagy and inhibiting oxidative stress. OPA1 may play an important role in the improvement of cardiac function and mitophagy pathway in myocardial infarction mice by irisin-mediated resistance exercise. Resistance exercise is expected to become an effective therapeutic way to promote myocardial infarction rehabilitation.

Citing Articles

The role and underlying mechanisms of irisin in exercise-mediated cardiovascular protection.

Guo W, Peng J, Su J, Xia J, Deng W, Li P PeerJ. 2024; 12:e18413.

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Irisin Protects Musculoskeletal Homeostasis via a Mitochondrial Quality Control Mechanism.

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Cardioprotective Effects of Exercise: The Role of Irisin and Exosome.

Wang Y, Yang Y, Song Y Curr Vasc Pharmacol. 2024; 22(5):316-334.

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The role of mitophagy in metabolic diseases and its exercise intervention.

Tang S, Geng Y, Lin Q Front Physiol. 2024; 15:1339128.

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