A Novel Fluorescent Probe for Hydrogen Peroxide and Its Application in Bio-Imaging

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2021 Jul 2

PMID 34199465

Citations 3

Authors

Yingying Zuo

Yang Jiao

Chunming Ma

Chunying Duan

Affiliations

Soon will be listed here.

Abstract

Hydrogen peroxide (HO) plays an important role in the human body and monitoring its level is meaningful due to the relationship between its level and diseases. A fluorescent sensor () based on coumarin was designed and its ability for detecting hydrogen peroxide by fluorescence signals was also studied. The showed an approximate 25-fold fluorescence enhancement after adding HO due to the interaction between the and HO and had the potential for detecting physiological HO. It also showed good biocompatibility and permeability, allowing it to penetrate cell membranes and zebrafish tissues, thus it can perform fluorescence imaging of HO in living cells and zebrafish. This probe is a promising tool for monitoring the level of HO in related physiological and pathological research.

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