Recent Advances in Organelle-Targeted Fluorescent Probes

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2021 Jan 7

PMID 33406634

Citations 16

Authors

Na-Eun Choi

Ji-Yu Lee

Eun-Chae Park

Ju-Hee Lee

Jiyoun Lee

Affiliations

Soon will be listed here.

Abstract

Recent advances in fluorescence imaging techniques and super-resolution microscopy have extended the applications of fluorescent probes in studying various cellular processes at the molecular level. Specifically, organelle-targeted probes have been commonly used to detect cellular metabolites and transient chemical messengers with high precision and have become invaluable tools to study biochemical pathways. Moreover, several recent studies reported various labeling strategies and novel chemical scaffolds to enhance target specificity and responsiveness. In this review, we will survey the most recent reports of organelle-targeted fluorescent probes and assess their general strategies and structural features on the basis of their target organelles. We will discuss the advantages of the currently used probes and the potential challenges in their application as well as future directions.

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