The Functionality of UDP-Glucuronosyltransferase Genetic Variants and Their Association with Drug Responses and Human Diseases

Overview

Journal J Pers Med

Date 2021 Jul 2

PMID 34198586

Citations 11

Authors

Yazun Jarrar

Su-Jun Lee

Affiliations

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Abstract

UDP-glucuronosyltransferases (UGTs) are phase II drug-metabolizing enzymes that metabolize endogenous fatty acids such as arachidonic acid metabolites, as well as many prescription drugs, such as opioids, antiepileptics, and antiviral drugs. The and genes are highly polymorphic, and their genetic variants may affect the pharmacokinetics and hence the responses of many drugs and fatty acids. This study collected data and updated the current view of the molecular functionality of genetic variants on genes that impact drug responses and the susceptibility to human diseases. The functional information of genetic variants with clinical associations are essential to understand the inter-individual variation in drug responses and susceptibility to toxicity.

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