A Diverse Collection of B Cells Responded to HIV Infection in Infant BG505

Overview

Journal Cell Rep Med

Publisher Cell Press

Specialties Biology
General Medicine

Date 2021 Jul 1

PMID 34195680

Citations 7

Authors

Cassandra Simonich

Mackenzie M Shipley

Laura Doepker

Theodore Gobillot

Meghan Garrett

Evan M Cale

Brianna Hennessy

Hannah Itell

Vrasha Chohan

Nicole Doria-Rose

Ruth Nduati

Julie Overbaugh

Affiliations

Soon will be listed here.

Abstract

Increasing evidence suggests infants develop unique neutralizing antibody (nAb) responses to HIV compared to adults. Here, we dissected the nAb response of an infant whose virus is in clinical trials as a vaccine immunogen, with a goal of characterizing the broad responses in the infant to this antigen. We isolated 73 nAbs from infant BG505 and identified a large number of clonal families. Twenty-six antibodies neutralized tier 2 viruses-in some cases, viruses from the same clade as BG505, and in others, a different clade, although none showed notable breadth. Several nAbs demonstrated antibody-dependent cellular cytotoxicity activity and targeted the V3 loop. These findings suggest an impressive polyclonal response to HIV infection in infant BG505, adding to the growing evidence that the nAb response to HIV in infants is polyclonal-a desirable vaccine response to a rapidly evolving virus like HIV.

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