Imbalanced Dietary Intake Alters the Colonic Microbial Profile in Growing Rats

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2021 Jun 30

PMID 34191855

Citations 1

Authors

Tae-Hwan Jung

Kyoung-Sik Han

Affiliations

Soon will be listed here.

Abstract

An imbalanced dietary intake is associated with alteration of intestinal ecosystem. We investigated the impact of imbalanced diets on colonic microbiota, concentrations of short chain fatty acid in colonic digesta and serum immunoglobulins (Igs) of growing rats. Compared to the control diet, consuming diets high in fat, sucrose, or processed meat, or low in iron, increased the abundance of the pathogenic bacteria such as Clostridium, Escherichia coli, and Salmonella species, and decreased the beneficial bacteria, like Bifidobacteria, Lactobacillus, Akkermansia, Phascolarctobacterium, Alistipes, and butyrate producing species of bacteria in the colon of growing rats. The heatmap of metagenomics indicated that each group was separated into distinct clusters, and the ID group in particular, showed significantly (P < 0.01) reduced alpha diversity of colonic microbiota in comparison to the control group. All experimental groups showed significantly (P < 0.05 or P < 0.01) decreased concentration of acetate and butyrate in the colonic digesta and lower levels of serum IgG or IgA, compared to the control. These results indicated that the imbalanced dietary intake negatively altered intestinal ecosystem and immunity.

Citing Articles

Intravenous ferric carboxymaltose and ferric derisomaltose alter the intestinal microbiome in female iron-deficient anemic mice.

Rieg T, Xue J, Stevens M, Thomas L, White J, Dominguez Rieg J Biosci Rep. 2023; 43(9).

PMID: 37671923 PMC: 10520285. DOI: 10.1042/BSR20231217.

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