Concept for Using Magnetic Particle Imaging for Intraoperative Margin Analysis in Breast-conserving Surgery

Overview

Journal Sci Rep

Specialty Science

Date 2021 Jun 30

PMID 34188077

Citations 9

Authors

Erica E Mason

Eli Mattingly

Konstantin Herb

Monika Sliwiak

Sofia Franconi

Clarissa Zimmerman Cooley

Priscilla J Slanetz

Lawrence L Wald

Affiliations

Soon will be listed here.

Abstract

Breast-conserving surgery (BCS) is a commonly utilized treatment for early stage breast cancers but has relatively high reexcision rates due to post-surgical identification of positive margins. A fast, specific, sensitive, easy-to-use tool for assessing margins intraoperatively could reduce the need for additional surgeries, and while many techniques have been explored, the clinical need is still unmet. We assess the potential of Magnetic Particle Imaging (MPI) for intraoperative margin assessment in BCS, using a passively or actively tumor-targeted iron oxide agent and two hardware devices: a hand-held Magnetic Particle detector for identifying residual tumor in the breast, and a small-bore MPI scanner for quickly imaging the tumor distribution in the excised specimen. Here, we present both hardware systems and demonstrate proof-of-concept detection and imaging of clinically relevant phantoms.

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References

Maeda H, Wu J, Sawa T, Matsumura Y, Hori K . Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release. 2000; 65(1-2):271-84. DOI: 10.1016/s0168-3659(99)00248-5. View

Grafe K, von Gladiss A, Bringout G, Ahlborg M, Buzug T . 2D Images Recorded With a Single-Sided Magnetic Particle Imaging Scanner. IEEE Trans Med Imaging. 2015; 35(4):1056-65. DOI: 10.1109/TMI.2015.2507187. View

Maloney B, McClatchy D, Pogue B, Paulsen K, Wells W, Barth R . Review of methods for intraoperative margin detection for breast conserving surgery. J Biomed Opt. 2018; 23(10):1-19. PMC: 6210801. DOI: 10.1117/1.JBO.23.10.100901. View

Nichols J, Bae Y . EPR: Evidence and fallacy. J Control Release. 2014; 190:451-64. DOI: 10.1016/j.jconrel.2014.03.057. View

Horst K, Smitt M, Goffinet D, Carlson R . Predictors of local recurrence after breast-conservation therapy. Clin Breast Cancer. 2005; 5(6):425-38. DOI: 10.3816/cbc.2005.n.001. View

Maeda H, Nakamura H, Fang J . The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo. Adv Drug Deliv Rev. 2012; 65(1):71-9. DOI: 10.1016/j.addr.2012.10.002. View

Schleich N, Po C, Jacobs D, Ucakar B, Gallez B, Danhier F . Comparison of active, passive and magnetic targeting to tumors of multifunctional paclitaxel/SPIO-loaded nanoparticles for tumor imaging and therapy. J Control Release. 2014; 194:82-91. DOI: 10.1016/j.jconrel.2014.07.059. View

McCready D . Keeping abreast of marginal controversies. Ann Surg Oncol. 2004; 11(10):885-7. DOI: 10.1245/ASO.2004.08.910. View

Gage I, Schnitt S, Nixon A, Silver B, Recht A, Troyan S . Pathologic margin involvement and the risk of recurrence in patients treated with breast-conserving therapy. Cancer. 1996; 78(9):1921-8. DOI: 10.1002/(sici)1097-0142(19961101)78:9<1921::aid-cncr12>3.0.co;2-#. View

10.

Erickson-Bhatt S, Nolan R, Shemonski N, Adie S, Putney J, Darga D . Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery. Cancer Res. 2015; 75(18):3706-12. PMC: 4749141. DOI: 10.1158/0008-5472.CAN-15-0464. View

11.

Daldrup-Link H, Golovko D, Ruffell B, DeNardo D, Castaneda R, Ansari C . MRI of tumor-associated macrophages with clinically applicable iron oxide nanoparticles. Clin Cancer Res. 2011; 17(17):5695-704. PMC: 3166957. DOI: 10.1158/1078-0432.CCR-10-3420. View

12.

Bauer L, Situ S, Griswold M, Samia A . Magnetic Particle Imaging Tracers: State-of-the-Art and Future Directions. J Phys Chem Lett. 2015; 6(13):2509-17. DOI: 10.1021/acs.jpclett.5b00610. View

13.

Harvey J, Lim Y, Murphy J, Howe M, Morris J, Goyal A . Safety and feasibility of breast lesion localization using magnetic seeds (Magseed): a multi-centre, open-label cohort study. Breast Cancer Res Treat. 2018; 169(3):531-536. PMC: 5953977. DOI: 10.1007/s10549-018-4709-y. View

14.

Kummerow K, Du L, Penson D, Shyr Y, Hooks M . Nationwide trends in mastectomy for early-stage breast cancer. JAMA Surg. 2014; 150(1):9-16. DOI: 10.1001/jamasurg.2014.2895. View

15.

Franke J, Heinen U, Lehr H, Weber A, Jaspard F, Ruhm W . System Characterization of a Highly Integrated Preclinical Hybrid MPI-MRI Scanner. IEEE Trans Med Imaging. 2016; 35(9):1993-2004. DOI: 10.1109/TMI.2016.2542041. View

16.

Morrow M, Abrahamse P, Hofer T, Ward K, Hamilton A, Kurian A . Trends in Reoperation After Initial Lumpectomy for Breast Cancer: Addressing Overtreatment in Surgical Management. JAMA Oncol. 2017; 3(10):1352-1357. PMC: 5710510. DOI: 10.1001/jamaoncol.2017.0774. View

17.

Franke J, Baxan N, Lehr H, Heinen U, Reinartz S, Schnorr J . Hybrid MPI-MRI System for Dual-Modal In Situ Cardiovascular Assessments of Real-Time 3D Blood Flow Quantification-A Pre-Clinical In Vivo Feasibility Investigation. IEEE Trans Med Imaging. 2020; 39(12):4335-4345. DOI: 10.1109/TMI.2020.3017160. View

18.

Keselman P, Yu E, Zhou X, Goodwill P, Chandrasekharan P, Ferguson R . Tracking short-term biodistribution and long-term clearance of SPIO tracers in magnetic particle imaging. Phys Med Biol. 2017; 62(9):3440-3453. PMC: 5739049. DOI: 10.1088/1361-6560/aa5f48. View

19.

Top C, Gungor A . Tomographic Field Free Line Magnetic Particle Imaging With an Open-Sided Scanner Configuration. IEEE Trans Med Imaging. 2020; 39(12):4164-4173. DOI: 10.1109/TMI.2020.3014197. View

20.

Du M, Ouyang Y, Meng F, Ma Q, Liu H, Zhuang Y . Nanotargeted agents: an emerging therapeutic strategy for breast cancer. Nanomedicine (Lond). 2019; 14(13):1771-1786. DOI: 10.2217/nnm-2018-0481. View