Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways

Overview

Journal mSystems

Publisher American Society for Microbiology

Specialty Microbiology

Date 2021 Jun 29

PMID 34184910

Citations 13

Authors

Nathan P Manes

Aleksandra Nita-Lazar

Affiliations

Soon will be listed here.

Abstract

Pattern recognition receptors (PRRs) form the front line of defense against pathogens. Many of the molecular mechanisms that facilitate PRR signaling have been characterized in detail, which is critical for the development of accurate PRR pathway models at the molecular interaction level. These models could support the development of therapeutics for numerous diseases, including sepsis and COVID-19. This review describes the molecular mechanisms of the principal signaling interactions of the Toll-like receptor, STING, MAVS, and inflammasome pathways. A detailed molecular mechanism network is included as Data Set S1 in the supplemental material.

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