The Relationship of Pre-corneal to Pre-contact Lens Non-invasive Tear Breakup Time

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2021 Jun 28

PMID 34181641

Citations 2

Authors

Andrew D Graham

Meng C Lin

Affiliations

Soon will be listed here.

Abstract

Purpose: To examine the relationship between pre-corneal and pre-contact lens tear film stability (TFS), and to determine whether pre-corneal TFS is a reliable predictor of subsequent pre-lens TFS after a contact lens is placed on the eye.

Methods: 667 records met inclusion criteria and were extracted from a soft contact lens multi-study database. Multivariable linear mixed effects models were fit to examine the association between pre-corneal and pre-lens TFS, adjusting for potential confounders and accounting for repeated measures. Receiver Operating Characteristic (ROC) analysis was employed to assess the predictive performance of pre-corneal TFS for subsequent pre-lens TFS. TFS was quantified for this analysis as the non-invasive tear breakup time (NITBUT).

Results: Pre-corneal NITBUT was significantly related to the pre-lens NITBUT at both 10 min (p<0.001) and 2-6 hrs (p<0.001) post-lens insertion. However, the sensitivities of pre-corneal NITBUT for predicting symptom-associated thresholds of pre-lens NITBUT ranged from 50-65%, and specificities ranged from 57-72%, suggesting poor-to-moderate diagnostic performance.

Conclusions: Despite the association of pre-corneal and pre-lens TFS, the inherent lability and sensitivity to environmental exposures of the tear film introduce significant variability into NITBUT measurements. Using pre-corneal NITBUT to identify likely successful contact lens candidates prior to fitting is thus not sufficiently accurate to be relied upon in the clinical setting.

Citing Articles

Patient Satisfaction and Tear Film Break-Up Time After First-Time Wearing of Silicone Hydrogel Contact Lenses.

Misu N, Mimura T, Noma H, Shinbo K Cureus. 2024; 16(1):e52516.

PMID: 38371096 PMC: 10874256. DOI: 10.7759/cureus.52516.

Pre-Lens Tear Meniscus Height, Lipid Layer Pattern and Non-Invasive Break-Up Time Short-Term Changes with a Water Gradient Silicone Hydrogel Contact Lens.

Capote-Puente R, Bautista-Llamas M, Manzoni C, Sanchez-Gonzalez J Life (Basel). 2022; 12(11).

PMID: 36362865 PMC: 9697334. DOI: 10.3390/life12111710.

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