Absence of Human Papillomavirus in Nasopharyngeal Swabs from Infants in a Population at High Risk of Human Papillomavirus Infection

Overview

Journal Pediatr Investig

Specialty Pediatrics

Date 2021 Jun 28

PMID 34179711

Citations 2

Authors

Heidi C Smith-Vaughan

Allen C Cheng

Sepehr N Tabrizi

Danielle F Wurzel

Jemima Beissbarth

Amanda J Leach

Peter S Morris

Michael J Binks

Paul J Torzillo

Anne B Chang

Robyn L Marsh

Affiliations

Soon will be listed here.

Abstract

Maternal urogenital human papillomavirus (HPV) infection may place neonates at risk of HPV acquisition and subsequently lower respiratory infections as HPV can influence development of immunity. The respiratory HPV prevalence is not known in remote-dwelling Aboriginal infants, who are at high risk of respiratory infection and where the population prevalence of urogenital HPV in women is high. These data are necessary to inform HPV vaccination regimens. A retrospective analysis using PCR specific for HPV was performed on 64 stored nasopharyngeal swabs from remote-dwelling Aboriginal infants < 6 months of age, with and without hospitalised pneumonia. HPV DNA was not detected in any specimen. Despite the negative result, we cannot exclude a role for HPV in respiratory infections affecting infants in this population; however, our data do not support HPV as an important contributor to acute respiratory infection in remote-dwelling Aboriginal children.

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PMID: 39192225 PMC: 11350954. DOI: 10.1186/s12985-024-02466-z.

Absence of human papillomavirus in nasopharyngeal swabs from infants in a population at high risk of human papillomavirus infection.

Smith-Vaughan H, Cheng A, Tabrizi S, Wurzel D, Beissbarth J, Leach A Pediatr Investig. 2021; 5(2):136-139.

PMID: 34179711 PMC: 8212721. DOI: 10.1002/ped4.12262.

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