Advances in Activity-based Diagnostics for Infectious Disease and Microbiome Health

Overview

Journal Curr Opin Biomed Eng

Specialty Biomedical Engineering

Date 2021 Jun 28

PMID 34179594

Citations 1

Authors

Leslie W Chan

Affiliations

Soon will be listed here.

Abstract

In the human body, pathogens and the endogenous microbiome produce enzymes that aid in replication and survival. The activity from these enzymes as well as energy-dependent transport processes can be used as functional biomarkers for pathogen identification, antimicrobial treatment monitoring, and surveillance of microbiome health. To produce visual and/or quantifiable readouts from this activity, concepts from chemical biology and nanomedicine have been utilized to develop signal-producing probes for patient samples or for direct administration . In the context of infection, activity-based diagnostics offer several potential advantages over current diagnostics including the ability to differentiate between active infection and sterile inflammation, which is made possible by targeting microbial enzymes with orthogonal activity to that of the host. In this review, we discuss new developments in the making of activity-based infection diagnostics and the beginnings of microbiome activity-based diagnostics.

Citing Articles

Microbiome as an immune regulator in health, disease, and therapeutics.

Juarez V, Montalbine A, Singh A Adv Drug Deliv Rev. 2022; 188:114400.

PMID: 35718251 PMC: 10751508. DOI: 10.1016/j.addr.2022.114400.

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