Bile Salt Hydrolases: Gatekeepers of Bile Acid Metabolism and Host-microbiome Crosstalk in the Gastrointestinal Tract

Overview

Journal PLoS Pathog

Specialty Microbiology

Date 2019 Mar 8

PMID 30845232

Citations 119

Authors

Matthew H Foley

Sarah OFlaherty

Rodolphe Barrangou

Casey M Theriot

Affiliations

Soon will be listed here.

Citing Articles

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References

Tanaka H, Hashiba H, Kok J, Mierau I . Bile salt hydrolase of Bifidobacterium longum-biochemical and genetic characterization. Appl Environ Microbiol. 2000; 66(6):2502-12. PMC: 110569. DOI: 10.1128/AEM.66.6.2502-2512.2000. View

Dussurget O, Cabanes D, Dehoux P, Lecuit M, Buchrieser C, Glaser P . Listeria monocytogenes bile salt hydrolase is a PrfA-regulated virulence factor involved in the intestinal and hepatic phases of listeriosis. Mol Microbiol. 2002; 45(4):1095-106. DOI: 10.1046/j.1365-2958.2002.03080.x. View

Taranto M, Fernandez Murga M, Lorca G, de Valdez G . Bile salts and cholesterol induce changes in the lipid cell membrane of Lactobacillus reuteri. J Appl Microbiol. 2003; 95(1):86-91. DOI: 10.1046/j.1365-2672.2003.01962.x. View

Rossocha M, Schultz-Heienbrok R, von Moeller H, Coleman J, Saenger W . Conjugated bile acid hydrolase is a tetrameric N-terminal thiol hydrolase with specific recognition of its cholyl but not of its tauryl product. Biochemistry. 2005; 44(15):5739-48. DOI: 10.1021/bi0473206. View

Begley M, Gahan C, Hill C . The interaction between bacteria and bile. FEMS Microbiol Rev. 2005; 29(4):625-51. DOI: 10.1016/j.femsre.2004.09.003. View

Ridlon J, Kang D, Hylemon P . Bile salt biotransformations by human intestinal bacteria. J Lipid Res. 2005; 47(2):241-59. DOI: 10.1194/jlr.R500013-JLR200. View

Begley M, Hill C, Gahan C . Bile salt hydrolase activity in probiotics. Appl Environ Microbiol. 2006; 72(3):1729-38. PMC: 1393245. DOI: 10.1128/AEM.72.3.1729-1738.2006. View

Kumar R, Brannigan J, Prabhune A, Pundle A, Dodson G, Dodson E . Structural and functional analysis of a conjugated bile salt hydrolase from Bifidobacterium longum reveals an evolutionary relationship with penicillin V acylase. J Biol Chem. 2006; 281(43):32516-25. DOI: 10.1074/jbc.M604172200. View

Hofmann A, Hagey L . Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell Mol Life Sci. 2008; 65(16):2461-83. PMC: 11131813. DOI: 10.1007/s00018-008-7568-6. View

10.

Jones B, Begley M, Hill C, Gahan C, Marchesi J . Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome. Proc Natl Acad Sci U S A. 2008; 105(36):13580-5. PMC: 2533232. DOI: 10.1073/pnas.0804437105. View

11.

Chiang J . Bile acids: regulation of synthesis. J Lipid Res. 2009; 50(10):1955-66. PMC: 2739756. DOI: 10.1194/jlr.R900010-JLR200. View

12.

Vavassori P, Mencarelli A, Renga B, Distrutti E, Fiorucci S . The bile acid receptor FXR is a modulator of intestinal innate immunity. J Immunol. 2009; 183(10):6251-61. DOI: 10.4049/jimmunol.0803978. View

13.

Dowd G, Joyce S, Hill C, Gahan C . Investigation of the mechanisms by which Listeria monocytogenes grows in porcine gallbladder bile. Infect Immun. 2010; 79(1):369-79. PMC: 3019883. DOI: 10.1128/IAI.00330-10. View

14.

Islam K, Fukiya S, Hagio M, Fujii N, Ishizuka S, Ooka T . Bile acid is a host factor that regulates the composition of the cecal microbiota in rats. Gastroenterology. 2011; 141(5):1773-81. DOI: 10.1053/j.gastro.2011.07.046. View

15.

Marchesini M, Connolly J, Delpino M, Baldi P, Mujer C, Delvecchio V . Brucella abortus choloylglycine hydrolase affects cell envelope composition and host cell internalization. PLoS One. 2011; 6(12):e28480. PMC: 3234258. DOI: 10.1371/journal.pone.0028480. View

16.

Lodola A, Branduardi D, De Vivo M, Capoferri L, Mor M, Piomelli D . A catalytic mechanism for cysteine N-terminal nucleophile hydrolases, as revealed by free energy simulations. PLoS One. 2012; 7(2):e32397. PMC: 3289653. DOI: 10.1371/journal.pone.0032397. View

17.

Li F, Jiang C, Krausz K, Li Y, Albert I, Hao H . Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity. Nat Commun. 2013; 4:2384. PMC: 6595219. DOI: 10.1038/ncomms3384. View

18.

Joyce S, MacSharry J, Casey P, Kinsella M, Murphy E, Shanahan F . Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut. Proc Natl Acad Sci U S A. 2014; 111(20):7421-6. PMC: 4034235. DOI: 10.1073/pnas.1323599111. View

19.

Nie Y, Hu J, Yan X . Cross-talk between bile acids and intestinal microbiota in host metabolism and health. J Zhejiang Univ Sci B. 2015; 16(6):436-46. PMC: 4471595. DOI: 10.1631/jzus.B1400327. View

20.

Fiorucci S, Distrutti E . Bile Acid-Activated Receptors, Intestinal Microbiota, and the Treatment of Metabolic Disorders. Trends Mol Med. 2015; 21(11):702-714. DOI: 10.1016/j.molmed.2015.09.001. View