Single-Cell Mapping of GLP-1 and GIP Receptor Expression in the Dorsal Vagal Complex

Overview

Journal Diabetes

Specialty Endocrinology

Date 2021 Jun 28

PMID 34176785

Citations 10

Authors

Mette Q Ludwig

Petar V Todorov

Kristoffer L Egerod

David P Olson

Tune H Pers

Affiliations

Soon will be listed here.

Abstract

The dorsal vagal complex (DVC) in the hindbrain, composed of the area postrema, nucleus of the solitary tract, and dorsal motor nucleus of the vagus, plays a critical role in modulating satiety. The incretins glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) act directly in the brain to modulate feeding, and receptors for both are expressed in the DVC. Given the impressive clinical responses to pharmacologic manipulation of incretin signaling, understanding the central mechanisms by which incretins alter metabolism and energy balance is of critical importance. Here, we review recent single-cell approaches used to detect molecular signatures of GLP-1 and GIP receptor-expressing cells in the DVC. In addition, we discuss how current advancements in single-cell transcriptomics, epigenetics, spatial transcriptomics, and circuit mapping techniques have the potential to further characterize incretin receptor circuits in the hindbrain.

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