Clinical Efficacy of Nanohydroxyapatite-containing Toothpaste at Relieving Dentin Hypersensitivity: an 8 Weeks Randomized Control Trial

Overview

Journal BDJ Open

Specialty Dentistry

Date 2021 Jun 26

PMID 34172718

Citations 12

Authors

Bennett Tochukwu Amaechi

Kelly C Lemke

Shyamali Saha

Minh N Luong

Jonathan Gelfond

Affiliations

Soon will be listed here.

Abstract

Objective: The objective of this study was to investigate and compare the effectiveness of several toothpastes containing nanohydroxyapatite (nano-HAP) to relieve dentin hypersensitivity (DHS) with that of a commercial desensitizing dentifrice containing calcium sodium phosphosilicate (CSPS).

Materials And Methods: In this double-blind, randomized, parallel-group clinical trial, patients diagnosed with DHS and qualified to participate were randomized into four groups: toothpaste containing 10% nano-HAP (10%nano-HAP), 15% nano-HAP (15%nano-HAP), 10% nano-HAP supplemented with potassium nitrate (KNO) (10%nano-HAPKN), or CSPS. Subjects' baseline and post-treatment sensitivities were assessed using visual analog scale (VAS) after the application of ice-cold and air stimuli. Subjects used their assigned toothpaste for routine toothbrushing twice daily. Post-treatment sensitivity was assessed every 2 or 8 weeks. Mean change in VAS (mm) from baseline at each time point were compared using random-intercept, mixed-model analysis and Duncan test (P < 0.05).

Results: With either air or cold stimulus, VAS indicated a significant (P < 0.001) reduction from baseline DHS at each time point with all test toothpastes. Among the nano-HAP toothpastes, 15%nano-HAP and 10%nano-HAPKN were consistent in DHS reduction with both stimuli. With either stimuli, the CSPS did not significantly differ from 15%nano-HAP and 10%nano-HAPKN at any time point.

Conclusions: Toothpaste containing nano-HAP (10 or 15%) alone or supplemented with KNO was as effective as CSPS for relief of DHS symptoms when used at least twice daily.

Citing Articles

Comparative Study of Anti-COVID Mouthwash and Remineralization Agents on Dentinal Tubular Occlusion: An Study.

Soleimanyfar M, Tabatabaei S J Int Soc Prev Community Dent. 2025; 14(6):453-460.

PMID: 39867632 PMC: 11756714. DOI: 10.4103/jispcd.jispcd_80_24.

Advancements in nanohydroxyapatite: synthesis, biomedical applications and composite developments.

Zhao R, Meng X, Pan Z, Li Y, Qian H, Zhu X Regen Biomater. 2025; 12:rbae129.

PMID: 39776858 PMC: 11703556. DOI: 10.1093/rb/rbae129.

Nanotechnology in toothpaste: Fundamentals, trends, and safety.

Abedi M, Ghasemi Y, Nemati M Heliyon. 2024; 10(3):e24949.

PMID: 38317872 PMC: 10838805. DOI: 10.1016/j.heliyon.2024.e24949.

Nanohydroxyapatite in dentistry: A comprehensive review.

Pushpalatha C, Gayathri V, Sowmya S, Augustine D, Alamoudi A, Zidane B Saudi Dent J. 2023; 35(6):741-752.

PMID: 37817794 PMC: 10562112. DOI: 10.1016/j.sdentj.2023.05.018.

Improving Oral Health with Fluoride-Free Calcium-Phosphate-Based Biomimetic Toothpastes: An Update of the Clinical Evidence.

Limeback H, Enax J, Meyer F Biomimetics (Basel). 2023; 8(4).

PMID: 37622936 PMC: 10452078. DOI: 10.3390/biomimetics8040331.

References

Irwin C, McCusker P . Prevalence of dentine hypersensitivity in a general dental population. J Ir Dent Assoc. 1997; 43(1):7-9. View

Schmidlin P, Sahrmann P . Current management of dentin hypersensitivity. Clin Oral Investig. 2013; 17 Suppl 1:S55-9. PMC: 3585982. DOI: 10.1007/s00784-012-0912-0. View

Rees J, Addy M . A cross-sectional study of dentine hypersensitivity. J Clin Periodontol. 2002; 29(11):997-1003. DOI: 10.1034/j.1600-051x.2002.291104.x. View

Luong M, Huang L, Chan D, Sadr A . In Vitro Study on the Effect of a New Bioactive Desensitizer on Dentin Tubule Sealing and Bonding. J Funct Biomater. 2020; 11(2). PMC: 7353572. DOI: 10.3390/jfb11020038. View

Poulsen S, Errboe M, Hovgaard O, Worthington H . Potassium nitrate toothpaste for dentine hypersensitivity. Cochrane Database Syst Rev. 2001; (2):CD001476. DOI: 10.1002/14651858.CD001476. View

Porto I, Andrade A, Montes M . Diagnosis and treatment of dentinal hypersensitivity. J Oral Sci. 2009; 51(3):323-32. DOI: 10.2334/josnusd.51.323. View

Jena A, Shashirekha G . Comparison of efficacy of three different desensitizing agents for in-office relief of dentin hypersensitivity: A 4 weeks clinical study. J Conserv Dent. 2015; 18(5):389-93. PMC: 4578184. DOI: 10.4103/0972-0707.164052. View

Mahesuti A, Duan Y, Wang G, Cheng X, Matis B . Short-term Efficacy of Agents Containing KNO3 or CPP-ACP in Treatment of Dentin Hypersensitivity. Chin J Dent Res. 2014; 17(1):43-7. View

Amaechi B, Lemke K, Saha S, Gelfond J . Clinical Efficacy in Relieving Dentin Hypersensitivity of Nanohydroxyapatite-containing Cream: A Randomized Controlled Trial. Open Dent J. 2018; 12:572-585. PMC: 6142669. DOI: 10.2174/1874210601812010572. View

10.

Tang B, Millar B . Effect of chewing gum on tooth sensitivity following whitening. Br Dent J. 2010; 208(12):571-7. DOI: 10.1038/sj.bdj.2010.500. View

11.

da Cruz L, Hill R, Chen X, Gillam D . Dentine Tubule Occlusion by Novel Bioactive Glass-Based Toothpastes. Int J Dent. 2018; 2018:5701638. PMC: 5904817. DOI: 10.1155/2018/5701638. View

12.

Sharma D, McGuire J, Gallob J, Amini P . Randomised clinical efficacy trial of potassium oxalate mouthrinse in relieving dentinal sensitivity. J Dent. 2013; 41 Suppl 4:S40-8. DOI: 10.1016/S0300-5712(13)70005-8. View

13.

Marto C, Paula A, Nunes T, Pimenta M, Abrantes A, Pires A . Evaluation of the efficacy of dentin hypersensitivity treatments-A systematic review and follow-up analysis. J Oral Rehabil. 2019; 46(10):952-990. DOI: 10.1111/joor.12842. View

14.

Sharma N, Roy S, Kakar A, Greenspan D, Scott R . A clinical study comparing oral formulations containing 7.5% calcium sodium phosphosilicate (NovaMin), 5% potassium nitrate, and 0.4% stannous fluoride for the management of dentin hypersensitivity. J Clin Dent. 2011; 21(3):88-92. View

15.

Shetty S, Kohad R, Yeltiwar R . Hydroxyapatite as an in-office agent for tooth hypersensitivity: a clinical and scanning electron microscopic study. J Periodontol. 2010; 81(12):1781-9. DOI: 10.1902/jop.2010.100172. View

16.

Tschoppe P, Zandim D, Martus P, Kielbassa A . Enamel and dentine remineralization by nano-hydroxyapatite toothpastes. J Dent. 2011; 39(6):430-7. DOI: 10.1016/j.jdent.2011.03.008. View

17.

Juntavee A, Juntavee N, Hirunmoon P . Remineralization Potential of Nanohydroxyapatite Toothpaste Compared with Tricalcium Phosphate and Fluoride Toothpaste on Artificial Carious Lesions. Int J Dent. 2021; 2021:5588832. PMC: 8007336. DOI: 10.1155/2021/5588832. View

18.

Godoy C, Consani S, Guimaraes A, Laurindo B, Mendonca M, Camilotti V . Effect of two desensitizing agents applied previous to in-office bleaching on the degree of whitening and dentin sensitivity: A randomized, controlled, double-blind clinical trial. Am J Dent. 2021; 34(2):70-74. View

19.

Chabanski M, Gillam D, Bulman J, Newman H . Prevalence of cervical dentine sensitivity in a population of patients referred to a specialist Periodontology Department. J Clin Periodontol. 1996; 23(11):989-92. DOI: 10.1111/j.1600-051x.1996.tb00525.x. View

20.

Vano M, Derchi G, Barone A, Pinna R, Usai P, Covani U . Reducing dentine hypersensitivity with nano-hydroxyapatite toothpaste: a double-blind randomized controlled trial. Clin Oral Investig. 2017; 22(1):313-320. DOI: 10.1007/s00784-017-2113-3. View