APOE E4 Genotypes Increase Risk of Delirium During COVID-19-Related Hospitalizations: Evidence From a Large UK Cohort

Overview

Journal J Gerontol A Biol Sci Med Sci

Specialty Geriatrics

Date 2021 Jun 25

PMID 34171089

Citations 8

Authors

Chia-Ling Kuo

Luke C Pilling

Janice L Atkins

Richard H Fortinsky

George A Kuchel

David Melzer

Affiliations

Soon will be listed here.

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ApoE4 associated with severe COVID-19 outcomes via downregulation of ACE2 and imbalanced RAS pathway.

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Delirium in the intensive care unit: identifying difficulties in applying the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU).

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Chemotherapy promotes astrocytic response to Aβ deposition, but not Aβ levels, in a mouse model of amyloid and APOE.

Ng C, Biran L, Galvano E, Mandelblatt J, Vicini S, Rebeck G Neurobiol Dis. 2022; 175:105915.

PMID: 36336241 PMC: 9794416. DOI: 10.1016/j.nbd.2022.105915.

References

Pilling L, Jones L, Masoli J, Delgado J, Atkins J, Bowden J . Low Vitamin D Levels and Risk of Incident Delirium in 351,000 Older UK Biobank Participants. J Am Geriatr Soc. 2020; 69(2):365-372. PMC: 7902418. DOI: 10.1111/jgs.16853. View

Pereira J, Aung Thein M, Nitchingham A, Caplan G . Delirium in older adults is associated with development of new dementia: a systematic review and meta-analysis. Int J Geriatr Psychiatry. 2021; 36(7):993-1003. DOI: 10.1002/gps.5508. View

Kuo C, Pilling L, Atkins J, Masoli J, Delgado J, Kuchel G . APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort. J Gerontol A Biol Sci Med Sci. 2020; 75(11):2231-2232. PMC: 7314139. DOI: 10.1093/gerona/glaa131. View

Kennedy M, Helfand B, Gou R, Gartaganis S, Webb M, Moccia J . Delirium in Older Patients With COVID-19 Presenting to the Emergency Department. JAMA Netw Open. 2020; 3(11):e2029540. PMC: 7677760. DOI: 10.1001/jamanetworkopen.2020.29540. View

Kuo C, Pilling L, Atkins J, Masoli J, Delgado J, Kuchel G . ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank. J Gerontol A Biol Sci Med Sci. 2020; 75(9):1801-1803. PMC: 7337688. DOI: 10.1093/gerona/glaa169. View