David Melzer
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Explore the profile of David Melzer including associated specialties, affiliations and a list of published articles.
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206
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16085
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Recent Articles
1.
Murrin O, Mounier N, Voller B, Tata L, Gallego-Moll C, Roso-Llorach A, et al.
EBioMedicine
. 2025 Feb;
113:105584.
PMID: 39919332
Background: Multimorbidity, the presence of two or more conditions in one person, is common but studies are often limited to observational data and single datasets. We address this gap by...
2.
Tian Q, Zweibaum D, Qian Y, Oppong R, Pilling L, Casanova F, et al.
Geroscience
. 2024 Sep;
47(1):825-835.
PMID: 39313624
Mitochondrial dysfunction is linked to physical impairment and dementia. Mitochondrial DNA copy number (mtDNAcn) from blood may predict cognitive decline and dementia risk, but the effect of somatic mutations or...
3.
Lucas M, Pilling L, Atkins J, Melzer D
Hepatology
. 2024 Aug;
PMID: 39178373
Background Aims: The HFE p.C282Y+/+ (homozygous) genotype and central adiposity both increase liver disease and diabetes risks, but combined effects are unclear. We estimated waist-to-hip ratio (WHR) associations with incident...
4.
Casanova F, Tian Q, Williamson D, Qian Y, Zweibaum D, Ding J, et al.
Neurobiol Dis
. 2024 May;
197:106539.
PMID: 38789058
Background: Iron overload is observed in neurodegenerative diseases, especially Alzheimer's disease (AD) and Parkinson's disease (PD). Homozygotes for the iron-overload (haemochromatosis) causing HFE p.C282Y variant have increased risk of dementia...
5.
Turkmen D, Bowden J, Masoli J, Melzer D, Pilling L
Int J Mol Sci
. 2024 Apr;
25(8).
PMID: 38674010
The solute carrier organic anion transporter family member 1B1 () encodes the organic anion-transporting polypeptide 1B1 (OATP1B1 protein) that transports statins to liver cells. Common genetic variants in , such...
6.
Turkmen D, Bowden J, Masoli J, Delgado J, Kuo C, Melzer D, et al.
Pharmacogenomics J
. 2024 Apr;
24(3):12.
PMID: 38632276
Pharmacogenetic variants are associated with clinical outcomes during Calcium Channel Blocker (CCB) treatment, yet whether the effects are modified by genetically predicted clinical risk factors is unknown. We analyzed 32,000...
7.
Lucas M, Atkins J, Pilling L, Shearman J, Melzer D
BMJ Open
. 2024 Mar;
14(3):e081926.
PMID: 38479735
Objectives: haemochromatosis genetic variants have an uncertain clinical penetrance, especially to older ages and in undiagnosed groups. We estimated p.C282Y and p.H63D variant cumulative incidence of multiple clinical outcomes in...
8.
Tian Q, Zweibaum D, Pilling L, Casanova F, Qian Y, Atkins J, et al.
Antioxid Redox Signal
. 2024 Jan;
40(16-18):990-997.
PMID: 38251633
No abstract available.
9.
Casanova F, Tian Q, Atkins J, Wood A, Williamson D, Qian Y, et al.
J Med Genet
. 2024 Jan;
61(5):435-442.
PMID: 38191510
Background: Brain iron deposition is common in dementia, but whether serum iron is a causal risk factor is unknown. We aimed to determine whether genetic predisposition to higher serum iron...
10.
Banfield L, Knapp K, Pilling L, Melzer D, Atkins J
JBMR Plus
. 2023 Oct;
7(10):e10794.
PMID: 37808392
The iron overload disorder hemochromatosis is primarily caused by the homozygous p.C282Y variant, but the scale of excess related musculoskeletal morbidity is uncertain. We estimated hemochromatosis-genotype associations with clinically diagnosed...