Palladium-catalyzed Remote -C-H Activation of Arenes Assisted by a Recyclable Pyridine-based Template

Overview

Journal Chem Sci

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2021 Jun 24

PMID 34163684

Citations 5

Authors

Xiaoxi Chen

Shuai Fan

Meng Zhang

Yuzhen Gao

Shangda Li

Gang Li

Affiliations

Soon will be listed here.

Abstract

Direct -selective C-H functionalization of arenes remains a daunting challenge and is still significantly restricted to a few scaffolds. Herein, we report an unprecedented pyridine-based -directing template (DT) assisted, Pd-catalyzed -C-H alkenylation of three classes of arenes, phenylpropanoic acids, 2-phenyl benzoic acids and benzyl alcohols, with a series of alkenes including perfluoroalkenes. Notably, the pyridine-based -DT could be easily synthesized and readily recycled under mild conditions. These results may find application in rapid construction of -substituted arenes and stimulate the exploration of novel methods for -C-H functionalization of arenes.

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