Searching for Female Reproductive Aging and Longevity Biomarkers

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2021 Jun 22

PMID 34156973

Citations 15

Authors

Svetlana Yureneva

Viktoriya Averkova

Denis Silachev

Andrey Donnikov

Alla Gavisova

Vladimir Serov

Gennady Sukhikh

Affiliations

Soon will be listed here.

Abstract

Female reproductive aging is, in a way, a biological phenomenon that develops along canonical molecular pathways; however, it has particular features. Recent studies revealed complexity of the interconnections between reproductive aging and aging of other systems, and even suggested a cause-effect uncertainty between them. It was also shown that reproductive aging can impact aging processes in an organism at the level of cells, tissues, organs, and systems. Women at the end of their reproductive lives are characterized by the accelerated incidence of age-related diseases. Timing of the onset of menarche and menopause and variability in the duration of reproductive life carry a latent social risk: not having enough information about the reproductive potential, women keep on postponing childbirth. Identification and use of the most accurate and sensitive aging biomarkers enable the prediction of menopause timing and quantification of the true biological and reproductive ages of an organism. We discuss current views on reproductive aging and peculiarities of using available biomarkers of aging. We also consider latest advances in the search for potential genetic markers of reproductive aging. Finally, we posit the importance of determining the female biological age and highlight potential research directions in this area.

Citing Articles

Inhibition of ferroptosis counteracts the advanced maternal age-induced oocyte deterioration.

Zeng W, Wang F, Cui Z, Zhang Y, Li Y, Li N Cell Death Differ. 2025; .

PMID: 39910323 DOI: 10.1038/s41418-025-01456-0.

Perspectives on biomarkers of reproductive aging for fertility and beyond.

Wang S, Ren J, Jing Y, Qu J, Liu G Nat Aging. 2024; 4(12):1697-1710.

PMID: 39672897 DOI: 10.1038/s43587-024-00770-5.

Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring.

Benonisdottir S, Straub V, Kong A, Mills M Nat Aging. 2024; 4(12):1745-1759.

PMID: 39672892 DOI: 10.1038/s43587-024-00733-w.

Reproductive Ageing: Inflammation, immune cells, and cellular senescence in the aging ovary.

Isola J, Hense J, Osorio C, Biswas S, Alberola-Ila J, Ocanas S Reproduction. 2024; 168(2).

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A Molecular Perspective and Role of NAD in Ovarian Aging.

Ahmed M, Riaz U, Lv H, Yang L Int J Mol Sci. 2024; 25(9).

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