Unraveling the Clinical Relevance of Ferroptosis-Related Genes in Human Ovarian Aging

Overview

Journal Reprod Sci

Publisher Springer

Specialty Reproductive Medicine

Date 2023 Jul 27

PMID 37500975

Authors

Pei-Hsuan Lin

Chia-Jung Li

Li-Te Lin

Wan-Ping Su

Jim Jinn-Chyuan Sheu

Zhi-Hong Wen

Jiin-Tsuey Cheng

Kuan-Hao Tsui

Affiliations

Soon will be listed here.

Abstract

Ferroptosis, a recently discovered form of cell death, has been implicated in various diseases. However, the genetic relationship between ferroptosis and ovarian aging has not been thoroughly investigated through informatics analysis. In this study, we conducted bioinformatics analysis using ovarian aging and ferroptosis datasets to identify potential ferroptosis-related genes using R software. The expression levels of these genes at different ages were analyzed using the GTEx public database. To validate these findings at the genetic level, we performed clinical infertility biopsies. Bioinformatics analysis of a mouse ovary dataset revealed significantly higher expression of Tfrc, Ncoa4, and Slc3a2 in the aging group compared to the young group, while Gpx4 showed the opposite pattern. Consistent results were observed in biopsies from clinically aged infertile patients. This study is the first to identify a ferroptosis-related gene associated with ovarian aging, highlighting its potential as a diagnostic biomarker.

Citing Articles

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