From Bench to Biomolecular Simulation: Phospholipid Modulation of Potassium Channels

Overview

Journal J Mol Biol

Publisher Elsevier

Specialties Microbiology
Molecular Biology

Date 2021 Jun 17

PMID 34139216

Citations 1

Authors

Tanadet Pipatpolkai

Daniel Quetschlich

Phillip J Stansfeld

Affiliations

Soon will be listed here.

Abstract

Potassium (K) ion channels are crucial in numerous cellular processes as they hyperpolarise a cell through K conductance, returning a cell to its resting potential. K channel mutations result in multiple clinical complications such as arrhythmia, neonatal diabetes and migraines. Since 1995, the regulation of K channels by phospholipids has been heavily studied using a range of interdisciplinary methods such as cellular electrophysiology, structural biology and computational modelling. As a result, K channels are model proteins for the analysis of protein-lipid interactions. In this review, we will focus on the roles of lipids in the regulation of K channels, and how atomic-level structures, along with experimental techniques and molecular simulations, have helped guide our understanding of the importance of phospholipid interactions.

Citing Articles

Identifying Membrane Protein-Lipid Interactions with Lipidomic Lipid Exchange-Mass Spectrometry.

Zhang G, Odenkirk M, Janczak C, Lee R, Richardson K, Wang Z J Am Chem Soc. 2023; 145(38):20859-20867.

PMID: 37700579 PMC: 10540470. DOI: 10.1021/jacs.3c05883.

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