α β Integrin: An Intriguing Target for COVID-19 and Related Diseases

Overview

Journal Chembiochem

Specialty Biochemistry

Date 2021 Jun 16

PMID 34132013

Citations 7

Authors

Kelly Bugatti

Affiliations

Soon will be listed here.

Abstract

The outbreak of SARS-CoV-2 has been an extraordinary event that constituted a global health emergency. As the novel coronavirus is continuing to spread over the world, the need for therapeutic agents to control this pandemic is increasing. α β Integrin may be an intriguing target not only for the inhibition of SARS-CoV-2 entry, but also for the diagnosis/treatment of COVID-19 related fibrosis, an emerging type of fibrotic disease which will probably affect a significant part of the recovered patients. In this short article, the possible role of this integrin for fighting COVID-19 is discussed on the basis of recently published evidence, showing how its underestimated involvement may be interesting for the development of novel pharmacological tools.

Citing Articles

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PMID: 38338840 PMC: 10855955. DOI: 10.3390/ijms25031562.

Gallium-68 labelled RGD PET/CT imaging of endothelial activation in COVID-19 patients.

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Inhibition of Cell Motility by Cell-Penetrating Dynamic Covalent Cascade Exchangers: Integrins Participate in Thiol-Mediated Uptake.

Coelho F, Saidjalolov S, Moreau D, Thorn-Seshold O, Matile S JACS Au. 2023; 3(4):1010-1016.

PMID: 37124287 PMC: 10131202. DOI: 10.1021/jacsau.3c00113.

Targeting integrin pathways: mechanisms and advances in therapy.

Pang X, He X, Qiu Z, Zhang H, Xie R, Liu Z Signal Transduct Target Ther. 2023; 8(1):1.

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Earliest histopathological changes in COVID-19 pneumonia with comprehensive gene expression analyses: A case series study.

Okudela K, Hayashi H, Yoshimura Y, Sasaki H, Miyata N, Iwashita H Histol Histopathol. 2022; 38(6):623-636.

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