Localized Neuroblastoma Treated by Surgery: a Pediatric Oncology Group Study

Overview

Journal J Clin Oncol

Specialty Oncology

Date 1988 Aug 1

PMID 3411339

Citations 21

Authors

R Nitschke

E I SMITH

S Shochat

G Altshuler

H Travers

J J Shuster

F A Hayes

R Patterson

N McWilliams

Affiliations

Soon will be listed here.

Abstract

A prospective study was designed to evaluate the outcome of patients with localized resectable neuroblastoma without regional lymph node involvement when no therapy beyond surgical resection was administered. One hundred one patients observed for 3 to 60 months had a 2-year disease-free survival of 89% (SE = 5%). Of the nine patients experiencing relapse, only three have died. There were no apparent distinguishing characteristics of the nine failures. Due to the favorable prognosis of the subset of neuroblastoma patients, prognostic factor analysis had very limited power and lacked clinical importance. Complete gross removal of the localized tumors is adequate therapy to ensure the survival of the majority of these patients.

Citing Articles

Impact of risk-based therapy on late morbidity and mortality in neuroblastoma survivors: a report from the Childhood Cancer Survivor Study.

Friedman D, Goodman P, Leisenring W, Diller L, Cohn S, Howell R J Natl Cancer Inst. 2024; 116(6):885-894.

PMID: 38460547 PMC: 11160496. DOI: 10.1093/jnci/djae062.

International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines.

Abib S, Chui C, Cox S, Abdelhafeez A, Fernandez-Pineda I, Elgendy A Ecancermedicalscience. 2022; 16:1356.

PMID: 35510137 PMC: 9023308. DOI: 10.3332/ecancer.2022.1356.

Long-Term Outcome and Role of Biology within Risk-Adapted Treatment Strategies: The Austrian Neuroblastoma Trial A-NB94.

Fiedler S, Ambros I, Glogova E, Benesch M, Urban C, Mayer M Cancers (Basel). 2021; 13(3).

PMID: 33540616 PMC: 7867286. DOI: 10.3390/cancers13030572.

The MDM2 inhibitor CGM097 combined with the BET inhibitor OTX015 induces cell death and inhibits tumor growth in models of neuroblastoma.

Maser T, Zagorski J, Kelly S, Ostrander A, Goodyke A, Nagulapally A Cancer Med. 2020; 9(21):8144-8158.

PMID: 33034426 PMC: 7643634. DOI: 10.1002/cam4.3407.

Horner syndrome: clinical perspectives.

Kanagalingam S, Miller N Eye Brain. 2017; 7:35-46.

PMID: 28539793 PMC: 5398733. DOI: 10.2147/EB.S63633.