The Role of Polyamines in Gastric Cancer

Overview

Journal Oncogene

Specialties Molecular Biology
Oncology

Date 2021 Jun 10

PMID 34108618

Citations 19

Authors

Kara M McNamara

Alain P Gobert

Keith T Wilson

Affiliations

Soon will be listed here.

Abstract

Advancements in our understanding of polyamine molecular and cellular functions have led to increased interest in targeting polyamine metabolism for anticancer therapeutic benefits. The polyamines putrescine, spermidine, and spermine are polycationic alkylamines commonly found in all living cells and are essential for cellular growth and survival. This review summarizes the existing research on polyamine metabolism and function, specifically the role of polyamines in gastric immune cell and epithelial cell function. Polyamines have been implicated in a multitude of cancers, but in this review, we focus on the role of polyamine dysregulation in the context of Helicobacter pylori-induced gastritis and subsequent progression to gastric cancer. Due to the emerging implication of polyamines in cancer development, there is an increasing number of promising clinical trials using agents to target the polyamine metabolic pathway for potential chemoprevention and anticancer therapy.

Citing Articles

Polyamines: Key Players in Immunometabolism and Immune Regulation.

Mahalingam S, Pandiyan P J Cell Immunol. 2024; 6(5):196-208.

PMID: 39717382 PMC: 11666123. DOI: 10.33696/immunology.6.206.

Spermine oxidase promotes Helicobacter pylori-mediated gastric carcinogenesis through acrolein production.

McNamara K, Sierra J, Latour Y, Hawkins C, Asim M, Williams K Oncogene. 2024; 44(5):296-306.

PMID: 39523394 PMC: 11779639. DOI: 10.1038/s41388-024-03218-7.

Mucosal microbiota characterization in gastric cancer identifies immune-activated-related transcripts relevant gastric microbiome signatures.

Qian C, Hui J, Peng Z, Sun X, Zhang J Front Immunol. 2024; 15:1435334.

PMID: 39376571 PMC: 11456469. DOI: 10.3389/fimmu.2024.1435334.

A Narrative Review: Immunometabolic Interactions of Host-Gut Microbiota and Botanical Active Ingredients in Gastrointestinal Cancers.

Li S, Feng W, Wu J, Cui H, Wang Y, Liang T Int J Mol Sci. 2024; 25(16).

PMID: 39201782 PMC: 11354385. DOI: 10.3390/ijms25169096.

Extracellular putrescine can augment the epithelial-mesenchymal transition of gastric cancer cells by promoting MAL2 expression by elevating H3K27ac in its promoter region.

Bi C, Li C, Xing L, Lu Z, Liu H, Hu T Am J Cancer Res. 2024; 14(6):2805-2822.

PMID: 39005660 PMC: 11236783. DOI: 10.62347/BEUV4081.

References

Rawla P, Barsouk A . Epidemiology of gastric cancer: global trends, risk factors and prevention. Prz Gastroenterol. 2019; 14(1):26-38. PMC: 6444111. DOI: 10.5114/pg.2018.80001. View

Correa P . Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res. 1992; 52(24):6735-40. View

Correa P, Piazuelo M, Wilson K . Pathology of gastric intestinal metaplasia: clinical implications. Am J Gastroenterol. 2010; 105(3):493-8. PMC: 2895407. DOI: 10.1038/ajg.2009.728. View

Correa P, Shiao Y . Phenotypic and genotypic events in gastric carcinogenesis. Cancer Res. 1994; 54(7 Suppl):1941s-1943s. View

Piazuelo M, Bravo L, Mera R, Camargo M, Bravo J, Delgado A . The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions. Gastroenterology. 2020; 160(4):1106-1117.e3. PMC: 7956231. DOI: 10.1053/j.gastro.2020.11.017. View

Ge S, Xia X, Ding C, Zhen B, Zhou Q, Feng J . A proteomic landscape of diffuse-type gastric cancer. Nat Commun. 2018; 9(1):1012. PMC: 5843664. DOI: 10.1038/s41467-018-03121-2. View

Hooi J, Lai W, Ng W, Suen M, Underwood F, Tanyingoh D . Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis. Gastroenterology. 2017; 153(2):420-429. DOI: 10.1053/j.gastro.2017.04.022. View

Wroblewski L, Peek Jr R, Wilson K . Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev. 2010; 23(4):713-39. PMC: 2952980. DOI: 10.1128/CMR.00011-10. View

Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M . Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001; 345(11):784-9. DOI: 10.1056/NEJMoa001999. View

10.

Romero-Gallo J, Harris E, Krishna U, Washington M, Perez-Perez G, Peek Jr R . Effect of Helicobacter pylori eradication on gastric carcinogenesis. Lab Invest. 2008; 88(3):328-36. PMC: 2833422. DOI: 10.1038/labinvest.3700719. View

11.

Ma J, Zhang L, Brown L, Li J, Shen L, Pan K . Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality. J Natl Cancer Inst. 2012; 104(6):488-92. PMC: 3309129. DOI: 10.1093/jnci/djs003. View

12.

You W, Brown L, Zhang L, Li J, Jin M, Chang Y . Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst. 2006; 98(14):974-83. DOI: 10.1093/jnci/djj264. View

13.

Mera R, Fontham E, Bravo L, Bravo J, Piazuelo M, Camargo M . Long term follow up of patients treated for Helicobacter pylori infection. Gut. 2005; 54(11):1536-40. PMC: 1462952. DOI: 10.1136/gut.2005.072009. View

14.

Camargo M, Piazuelo M, Mera R, Fontham E, Delgado A, Yepez M . Effect of smoking on failure of H. pylori therapy and gastric histology in a high gastric cancer risk area of Colombia. Acta Gastroenterol Latinoam. 2008; 37(4):238-45. PMC: 4181574. View

15.

Blaser M . Ecology of Helicobacter pylori in the human stomach. J Clin Invest. 1997; 100(4):759-62. PMC: 508245. DOI: 10.1172/JCI119588. View

16.

Mera R, Bravo L, Camargo M, Bravo J, Delgado A, Romero-Gallo J . Dynamics of infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial. Gut. 2017; 67(7):1239-1246. PMC: 5742304. DOI: 10.1136/gutjnl-2016-311685. View

17.

Oliveira C, Pinheiro H, Figueiredo J, Seruca R, Carneiro F . Familial gastric cancer: genetic susceptibility, pathology, and implications for management. Lancet Oncol. 2015; 16(2):e60-70. DOI: 10.1016/S1470-2045(14)71016-2. View

18.

Kountouras J, Zavos C, Chatzopoulos D . New concepts of molecular biology on gastric carcinogenesis. Hepatogastroenterology. 2005; 52(64):1305-12. View

19.

Li D, Lo W, Rudloff U . Merging perspectives: genotype-directed molecular therapy for hereditary diffuse gastric cancer (HDGC) and E-cadherin-EGFR crosstalk. Clin Transl Med. 2018; 7(1):7. PMC: 5821620. DOI: 10.1186/s40169-018-0184-7. View

20.

Hardbower D, Peek Jr R, Wilson K . At the Bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer. J Leukoc Biol. 2014; 96(2):201-12. PMC: 4101087. DOI: 10.1189/jlb.4BT0214-099R. View