Polyamines: Key Players in Immunometabolism and Immune Regulation

Overview

Journal J Cell Immunol

Date 2024 Dec 24

PMID 39717382

Authors

Shanmuga S Mahalingam

Pushpa Pandiyan

Affiliations

Soon will be listed here.

Abstract

Polyamines are small organic molecules ubiquitously present in all living organisms and function as crucial regulators of biological processes ranging from fundamental cellular metabolism to immune regulation. Dysregulation of polyamine metabolism has been implicated in numerous diseases, including neurodegenerative disorders, inflammatory conditions, autoimmune diseases, and cancer. This review provides an overview of pathophysiology of these conditions, highlighting polyamines' role in immunometabolic alterations in the context of immune regulation. Exploring the intricate mechanisms of polyamine metabolism holds promise for advancing our understanding of disease processes and developing potential innovative therapeutic interventions.

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