Characteristics of Central Visual Field Progression in Eyes with Optic Disc Hemorrhage

Overview

Journal Am J Ophthalmol

Specialty Ophthalmology

Date 2021 Jun 9

PMID 34107310

Citations 6

Authors

Ryan Caezar C David

Sasan Moghimi

Jiun L Do

Huiyuan Hou

James Proudfoot

Linda M Zangwill

Alireza Kamalipour

Takashi Nishida

Carlos Gustavo De Moraes

Christopher A Girkin

Jeffrey M Liebmann

Robert N Weinreb

Affiliations

Soon will be listed here.

Abstract

Purpose: To investigate the characteristics and rate of central visual field loss after optic disc hemorrhage (DH).

Design: Prospective cohort study.

Methods: Three hundred forty-three eyes of 220 subjects who had ≥3 years of follow-up with a minimum of 5 visits with 10-2 and 24-2 visual field (VF) were recruited. Rates of 10-2 mean deviation (MD) loss in each hemifield and predefined zones were compared using linear mixed-effects models in DH and non-DH eyes. Clustered pointwise regression analysis was also used to define central VF progressors and compared with 24-2 VF loss using guided progression analysis.

Results: Thirty-nine eyes with DH and 304 eyes without DH had a mean follow-up of 5.2 years. Eyes with DH had rates of 10-2 MD loss that were 3 times faster than non-DH eyes (mean difference -0.36 dB/year [95% confidence interval 0.54-0.18]; P < .001) and were 3.7 times more likely to progress (P = .002). A larger proportion of glaucomatous eyes showed central VF progression rather than peripheral VF progression in the DH group (30.8% vs. 20.5%) compared with the non-DH group (10.9% vs. 9.2%). In early glaucoma, the rate of 10-2 MD loss was 5.5 times faster in DH eyes than in non-DH eyes (P < .001). Superonasal and superotemporal central VF regions progressed more rapidly than other regions, especially in DH eyes.

Conclusion: Central VF loss is accelerated in glaucoma eyes with DH and it corresponds topographically to the DH location. In patients with glaucoma with DH, one should consider supplementing 10-2 VFs with 24-2 VFS to monitor the disease.

Citing Articles

Central visual field in glaucoma: An updated review.

Du K, Kamalipour A, Moghimi S Taiwan J Ophthalmol. 2024; 14(3):360-370.

PMID: 39430344 PMC: 11488810. DOI: 10.4103/tjo.TJO-D-24-00042.

To identify risk factors for central visual field progression in moderate to advanced glaucoma.

Patil T, Natarajan V, George R Indian J Ophthalmol. 2024; 72(12):1734-1740.

PMID: 39141492 PMC: 11727959. DOI: 10.4103/IJO.IJO_2735_23.

Papillary and Peripapillary Hemorrhages in Eyes With Pathologic Myopia.

Xiong J, Du R, Xie S, Lu H, Chen C, Lgarashi-Yokoi T Invest Ophthalmol Vis Sci. 2022; 63(12):28.

PMID: 36409214 PMC: 9695143. DOI: 10.1167/iovs.63.12.28.

The number of examinations required for the accurate prediction of the progression of the central 10-degree visual field test in glaucoma.

Omoto T, Asaoka R, Akagi T, Oishi A, Miyata M, Murata H Sci Rep. 2022; 12(1):18843.

PMID: 36344722 PMC: 9640563. DOI: 10.1038/s41598-022-23604-z.

Association of macular vessel density and ganglion cell complex thickness with central visual field progression in glaucoma.

Wu J, Moghimi S, Nishida T, Mahmoudinezhad G, Zangwill L, Weinreb R Br J Ophthalmol. 2022; 107(12):1828-1833.

PMID: 36150750 PMC: 10033463. DOI: 10.1136/bjo-2022-321870.

References

Keltner J, Johnson C, Anderson D, Levine R, Fan J, Cello K . The association between glaucomatous visual fields and optic nerve head features in the Ocular Hypertension Treatment Study. Ophthalmology. 2006; 113(9):1603-12. DOI: 10.1016/j.ophtha.2006.05.061. View

Heijl A, Leske M, Bengtsson B, Bengtsson B, Hussein M . Measuring visual field progression in the Early Manifest Glaucoma Trial. Acta Ophthalmol Scand. 2003; 81(3):286-93. DOI: 10.1034/j.1600-0420.2003.00070.x. View

Hood D, Raza A, De Moraes C, Liebmann J, Ritch R . Glaucomatous damage of the macula. Prog Retin Eye Res. 2012; 32:1-21. PMC: 3529818. DOI: 10.1016/j.preteyeres.2012.08.003. View

Henson D, Hobley A . Frequency distribution of early glaucomatous visual field defects. Am J Optom Physiol Opt. 1986; 63(6):455-61. DOI: 10.1097/00006324-198606000-00010. View

Gardiner S, Mansberger S, Demirel S . Detection of Functional Change Using Cluster Trend Analysis in Glaucoma. Invest Ophthalmol Vis Sci. 2017; 58(6):BIO180-BIO190. PMC: 5516565. DOI: 10.1167/iovs.17-21562. View

Leske M, Heijl A, Hussein M, Bengtsson B, Hyman L, Komaroff E . Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial. Arch Ophthalmol. 2003; 121(1):48-56. DOI: 10.1001/archopht.121.1.48. View

Shukla A, Sirinek P, De Moraes C, Blumberg D, Cioffi G, Skaat A . Disc Hemorrhages Are Associated With the Presence and Progression of Glaucomatous Central Visual Field Defects. J Glaucoma. 2020; 29(6):429-434. PMC: 7272303. DOI: 10.1097/IJG.0000000000001487. View

Weinreb R, Aung T, Medeiros F . The pathophysiology and treatment of glaucoma: a review. JAMA. 2014; 311(18):1901-11. PMC: 4523637. DOI: 10.1001/jama.2014.3192. View

De Moraes C, Hood D, Thenappan A, Girkin C, Medeiros F, Weinreb R . 24-2 Visual Fields Miss Central Defects Shown on 10-2 Tests in Glaucoma Suspects, Ocular Hypertensives, and Early Glaucoma. Ophthalmology. 2017; 124(10):1449-1456. PMC: 5610609. DOI: 10.1016/j.ophtha.2017.04.021. View

10.

Richman J, Lorenzana L, Lankaranian D, Dugar J, Mayer J, Wizov S . Relationships in glaucoma patients between standard vision tests, quality of life, and ability to perform daily activities. Ophthalmic Epidemiol. 2010; 17(3):144-51. DOI: 10.3109/09286581003734878. View

11.

Hood D . Improving our understanding, and detection, of glaucomatous damage: An approach based upon optical coherence tomography (OCT). Prog Retin Eye Res. 2016; 57:46-75. PMC: 5350042. DOI: 10.1016/j.preteyeres.2016.12.002. View

12.

Park S, Kung Y, Su D, Simonson J, Furlanetto R, Liebmann J . Parafoveal scotoma progression in glaucoma: humphrey 10-2 versus 24-2 visual field analysis. Ophthalmology. 2013; 120(8):1546-50. DOI: 10.1016/j.ophtha.2013.01.045. View

13.

Gould R, Abramson I, Galasko D, Salmon D . Rate of cognitive change in Alzheimer's disease: methodological approaches using random effects models. J Int Neuropsychol Soc. 2002; 7(7):813-24. View

14.

Sonnsjo B, Dokmo Y, Krakau T . Disc haemorrhages, precursors of open angle glaucoma. Prog Retin Eye Res. 2002; 21(1):35-56. DOI: 10.1016/s1350-9462(01)00019-2. View

15.

Kim J, Kyung H, Azarbod P, Lee J, Caprioli J . Disc haemorrhage is associated with the fast component, but not the slow component, of visual field decay rate in glaucoma. Br J Ophthalmol. 2014; 98(11):1555-9. DOI: 10.1136/bjophthalmol-2013-304584. View

16.

McNaught A, Crabb D, Fitzke F, Hitchings R . Visual field progression: comparison of Humphrey Statpac2 and pointwise linear regression analysis. Graefes Arch Clin Exp Ophthalmol. 1996; 234(7):411-8. DOI: 10.1007/BF02539406. View

17.

Wu Z, Medeiros F, Weinreb R, Zangwill L . Performance of the 10-2 and 24-2 Visual Field Tests for Detecting Central Visual Field Abnormalities in Glaucoma. Am J Ophthalmol. 2018; 196:10-17. PMC: 6258276. DOI: 10.1016/j.ajo.2018.08.010. View

18.

Jonas J, Iester M . Disc hemorrhage and glaucoma. Ophthalmology. 1995; 102(3):365-6. DOI: 10.1016/s0161-6420(13)30831-8. View

19.

Hsia Y, Su C, Wang T, Huang J . Clinical characteristics of glaucoma patients with disc hemorrhage in different locations. Graefes Arch Clin Exp Ophthalmol. 2019; 257(9):1955-1962. DOI: 10.1007/s00417-019-04379-y. View

20.

Ekici F, Loh R, Waisbourd M, Sun Y, Martinez P, Nayak N . Relationships Between Measures of the Ability to Perform Vision-Related Activities, Vision-Related Quality of Life, and Clinical Findings in Patients With Glaucoma. JAMA Ophthalmol. 2015; 133(12):1377-85. DOI: 10.1001/jamaophthalmol.2015.3426. View