Synthetic Magainin Analogues with Improved Antimicrobial Activity

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 1988 Aug 29

PMID 3410055

Citations 54

Authors

H C Chen

J H Brown

J L. Morell

C M Huang

Affiliations

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Abstract

Based on modifications to enhance the alpha-helical structure of the broad spectrum antibiotic magainin 2, a series of analogues have been synthesized which display an increase up to two orders of magnitude in antimicrobial activity and, in the most favorable case, no appreciable increase in hemolytic activity over magainin 1 at the concentrations tested.

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