Roles of D-Amino Acids on the Bioactivity of Host Defense Peptides

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2016 Jul 5

PMID 27376281

Citations 32

Authors

Hao Li

Nuttapat Anuwongcharoen

Aijaz Ahmad Malik

Virapong Prachayasittikul

Jarl E S Wikberg

Chanin Nantasenamat

Affiliations

Soon will be listed here.

Abstract

Host defense peptides (HDPs) are positively-charged and amphipathic components of the innate immune system that have demonstrated great potential to become the next generation of broad spectrum therapeutic agents effective against a vast array of pathogens and tumor. As such, many approaches have been taken to improve the therapeutic efficacy of HDPs. Amongst these methods, the incorporation of d-amino acids (d-AA) is an approach that has demonstrated consistent success in improving HDPs. Although, virtually all HDP review articles briefly mentioned about the role of d-AA, however it is rather surprising that no systematic review specifically dedicated to this topic exists. Given the impact that d-AA incorporation has on HDPs, this review aims to fill that void with a systematic discussion of the impact of d-AA on HDPs.

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