Safety and Efficacy of Landiolol Hydrochloride in Children with Tachyarrhythmia of Various Etiologies

Overview

Journal Pediatr Cardiol

Specialties Cardiology & Vascular Diseases
Pediatrics

Date 2021 Jun 7

PMID 34097085

Citations 2

Authors

Atsuko Ashida

Noriyasu Ozaki

Kanta Kishi

Yutaka Odanaka

Shintaro Nemoto

Hayato Konishi

Akira Ashida

Affiliations

Soon will be listed here.

Abstract

The safety and efficacy of landiolol have not been fully elucidated in pediatric patients. This study aimed to clarify the safety and efficacy of landiolol in a pediatric cohort. We retrospectively assessed the clinical features of 21 pediatric patients who were administered landiolol at our hospital. We also investigated the rates of sinus rhythm conversion and heart rate response. The median patient age was 7 months (interquartile range 1-13 months). The etiology of tachyarrhythmia was junctional ectopic tachycardia in 10 patients (47.6%), atrial tachycardia in 10 patients (47.6%), and ventricular tachycardia in 1 patient (4.8%). Of the 21 children, 18 (85.7%) had congenital heart defects, including 14 (77.8%) in whom a landiolol infusion was performed perioperatively. The landiolol infusion was effective in 18 pediatric patients (85.7%), as measured by the conversion to sinus rhythm or a reduced heart rate. Atrial tachycardia in the perioperative period was terminated in all patients. Of 7 patients with tachyarrhythmias unrelated to the perioperative period, landiolol was effective in 5. No adverse effects were reported in any patient. Landiolol infusion is effective and safe in pediatric patients with tachyarrhythmia of various etiologies, especially those with atrial tachyarrhythmia during the perioperative period.

Citing Articles

Heart Rate Control with Landiolol Hydrochloride in Infants and Neonates During Cardiac Surgery.

Muller M, Puschmann L, Zajonz T, Unger M, Ackerl J, Shatilova O Pediatr Cardiol. 2025; .

PMID: 40064651 DOI: 10.1007/s00246-025-03824-6.

Landiolol is effective and safe in paediatric supraventricular tachycardia: evidence from a European prospective multicentre open-label phase III study (LANDI-PED).

Michel-Behnke I, Muller M, Stiller B, Kriebel T, Kanaan M, Kornyei L Europace. 2025; 27(2).

PMID: 39947241 PMC: 11879349. DOI: 10.1093/europace/euaf025.

Antiarrhythmic Drug Dosing in Children-Review of the Literature.

Oeffl N, Schober L, Faudon P, Schweintzger S, Manninger M, Kostenberger M Children (Basel). 2023; 10(5).

PMID: 37238395 PMC: 10217455. DOI: 10.3390/children10050847.

Heart rate control with landiolol hydrochloride in infants with ventricular dysfunction and pulmonary hypertension.

Schroeder L, Monno P, Unger M, Ackerl J, Shatilova O, Schmitt J ESC Heart Fail. 2022; 10(1):385-396.

PMID: 36256500 PMC: 9871696. DOI: 10.1002/ehf2.14202.

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