Development of a Highly Cardioselective Ultra Short-acting Beta-blocker, ONO-1101

Overview

Journal Chem Pharm Bull (Tokyo)

Specialties Chemistry
Pharmacology

Date 1992 Jun 1

PMID 1356643

Citations 60

Authors

S Iguchi

H Iwamura

M Nishizaki

A Hayashi

K Senokuchi

K Kobayashi

K Sakaki

K Hachiya

Y Ichioka

M Kawamura

Affiliations

Soon will be listed here.

Abstract

A novel, highly cardioselective ultra short-acting beta-blocker, ONO-1101, has been developed for application in the emergency treatment of tachycardia and better control of heart rate in surgery. This agent is approximately nine times more potent in beta-blocking activity in vivo and eight times more cardioselective in vitro than esmolol. This beta-blocking drug has a short duration of activity, enabling rapid recovery after cessation of administration if side effects occur. It can be used safely in patients suffering from acute heart disease and represents a major therapeutic advance in the treatment of heart disease.

Citing Articles

Heart Rate Control with Landiolol Hydrochloride in Infants and Neonates During Cardiac Surgery.

Muller M, Puschmann L, Zajonz T, Unger M, Ackerl J, Shatilova O Pediatr Cardiol. 2025; .

PMID: 40064651 DOI: 10.1007/s00246-025-03824-6.

Landiolol is effective and safe in paediatric supraventricular tachycardia: evidence from a European prospective multicentre open-label phase III study (LANDI-PED).

Michel-Behnke I, Muller M, Stiller B, Kriebel T, Kanaan M, Kornyei L Europace. 2025; 27(2).

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The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Randomised Study.

Thomas J, McGee K, Hossain A, Perkins G, Gordon A, Young D Intensive Care Med Exp. 2025; 13(1):9.

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Comparison of the efficacy and safety of Landiolol and Esmolol in critically ill patients: a propensity score-matched study.

Si X, Yuan H, Shi R, Song W, Guo J, Jiang J Ann Intensive Care. 2025; 15(1):5.

PMID: 39800840 PMC: 11725550. DOI: 10.1186/s13613-024-01418-8.

Computed tomography angiography assessment of Adamkiewicz artery with sublingual nitroglycerin administration.

Higuchi A, Kubota Y, Yokota H, Miyazaki H, Ota J, Okafuji Y Neuroradiology. 2024; 66(12):2215-2221.

PMID: 39102086 DOI: 10.1007/s00234-024-03433-9.