An Updated Systematic Review and Meta-analysis on Antibiotic Resistance in Iran (2013-2020)

Overview

Journal Iran J Basic Med Sci

Publisher Mashhad University of Medical Sciences

Specialty General Medicine

Date 2021 Jun 7

PMID 34094023

Citations 6

Authors

Farzad Khademi

Amirhossein Sahebkar

Affiliations

Soon will be listed here.

Abstract

This updated systematic review and meta-analysis follows two aims: 1) to assess antibiotic resistance in Iran from 2013 to 2020 and, 2) to assess the trend of resistance from 1999 to 2020. Several national and international databases were systematically searched through MeSH extracted keywords to identify 41 published studies addressing drug-resistant in Iran. Meta-analysis was done based on the PRISMA protocols using Comprehensive Meta-Analysis software. The average prevalence of resistance to first- and second-line anti-TB drugs, multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) in new and previously treated tuberculosis (TB) cases in Iran during 2013-2020 were as follows: isoniazid 6.9%, rifampin 7.9%, ethambutol 5.7%, pyrazinamide 20.4%, -aminosalicylic acid 4.6%, capreomycin 1.7%, cycloserine 1.8%, ethionamide 11.3%, ofloxacin 1.5%, kanamycin 3.8%, amikacin 2.2%, MDR-TB 6.3% and XDR-TB 0.9%. Based on the presented data, resistance to first- and second-line anti-TB drugs, as well as MDR-TB, was low during 2013-2020 in Iran. Furthermore, there was a declining trend in TB drug resistance from 1999 to 2020. Hence, to maintain the current decreasing trend and to control and eliminate TB infection in Iran, continuous monitoring of resistance patterns is recommended.

Citing Articles

Drug resistance and genomic variations among Mycobacterium tuberculosis isolates from The Nile Delta, Egypt.

Soliman M, Hansen C, Hanafy M, Shawky S, Rashed H, Abdullah M Sci Rep. 2024; 14(1):20401.

PMID: 39223176 PMC: 11369133. DOI: 10.1038/s41598-024-70199-8.

Bayesian estimation of the time-varying reproduction number for pulmonary tuberculosis in Iran: A registry-based study from 2018 to 2022 using new smear-positive cases.

Rastegar M, Nazar E, Nasehi M, Sharafi S, Fakoor V, Shakeri M Infect Dis Model. 2024; 9(3):963-974.

PMID: 38873589 PMC: 11169078. DOI: 10.1016/j.idm.2024.05.003.

Epidemiology of first- and second-line drugs-resistant pulmonary tuberculosis in Iran: Systematic review and meta-analysis.

Abbasian S, Heidari H, Tadi D, Kardan-Yamchi J, Taji A, Darbandi A J Clin Tuberc Other Mycobact Dis. 2024; 35:100430.

PMID: 38560029 PMC: 10981085. DOI: 10.1016/j.jctube.2024.100430.

Factors Associated with Non-Adherence to Treatment Among Migrants with MDR-TB in Wuhan, China: A Cross-Sectional Study.

Lin K, Xiang L Risk Manag Healthc Policy. 2024; 17:727-737.

PMID: 38559871 PMC: 10981374. DOI: 10.2147/RMHP.S448706.

Molecular identification of multiple drug resistance (MDR) strain of Mycobacterium tuberculosis.

Hosseinali Z, Mohammadshahi J, Teimourpour A, Habibzadeh S, Esmaelizad M, Arzanlou M Mol Biol Rep. 2023; 50(12):10271-10275.

PMID: 37971566 DOI: 10.1007/s11033-023-08867-7.

References

Pooideh M, Jabbarzadeh I, Ranjbar R, Saifi M . Molecular Epidemiology of Mycobacterium tuberculosis Isolates in 100 Patients With Tuberculosis Using Pulsed Field Gel Electrophoresis. Jundishapur J Microbiol. 2015; 8(7):e18274. PMC: 4575773. DOI: 10.5812/jjm.8(5)2015.18274. View

Khademi F, Yousefi A, Derakhshan M, Najafi A, Tafaghodi M . Enhancing immunogenicity of novel multistage subunit vaccine of using PLGA:DDA hybrid nanoparticles and MPLA: Subcutaneous administration. Iran J Basic Med Sci. 2019; 22(8):893-900. PMC: 6760476. DOI: 10.22038/ijbms.2019.33962.8079. View

Mansoori N, Yaseri M, Vaziri F, Douraghi M . Genetic diversity of Mycobacterium tuberculosis complex isolates circulating in an area with high tuberculosis incidence: Using 24-locus MIRU-VNTR method. Tuberculosis (Edinb). 2018; 112:89-97. DOI: 10.1016/j.tube.2018.08.003. View

Khanipour S, Ebrahimzadeh N, Masoumi M, Sakhaei F, Alinezhad F, Safarpour E . Haarlem 3 is the predominant genotype family in multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis in the capital of Iran: A 5-year survey. J Glob Antimicrob Resist. 2016; 5:7-10. DOI: 10.1016/j.jgar.2016.01.007. View

Karimi S, Mirhendi H, Zaniani F, Manesh S, Salehi M, Esfahani B . Rapid Detection of Streptomycin-Resistant by -Restriction Fragment Length Polymorphism. Adv Biomed Res. 2017; 6:126. PMC: 5672647. DOI: 10.4103/abr.abr_240_16. View

Babamahmoodi F, Mahdavi M, Jalali H, Talebi B, Roshan P, Mahdavi M . Evaluation of gene mutations involved in drug resistance in mycobacterium tuberculosis strains derived from tuberculosis patients in mazandaran, iran, 2013. Int J Mol Cell Med. 2014; 3(3):190-5. PMC: 4170493. View

Khademi F, Derakhshan M, Yousefi-Avarvand A, Tafaghodi M, Soleimanpour S . Multi-stage subunit vaccines against Mycobacterium tuberculosis: an alternative to the BCG vaccine or a BCG-prime boost?. Expert Rev Vaccines. 2017; 17(1):31-44. DOI: 10.1080/14760584.2018.1406309. View

Khademi F, Taheri R, Momtazi-Borojeni A, Farnoosh G, Johnston T, Sahebkar A . Potential of Cationic Liposomes as Adjuvants/Delivery Systems for Tuberculosis Subunit Vaccines. Rev Physiol Biochem Pharmacol. 2018; 175:47-69. DOI: 10.1007/112_2018_9. View

Nasiri M, Dabiri H, Darban-Sarokhalil D, Rezadehbashi M, Zamani S . Prevalence of drug-resistant tuberculosis in Iran: systematic review and meta-analysis. Am J Infect Control. 2014; 42(11):1212-8. DOI: 10.1016/j.ajic.2014.07.017. View

10.

Khosravi A, Sirous M, Absalan Z, Tabandeh M, Savari M . Comparison Of And Efflux Pump Genes Expression In Drug-Susceptible And -Resistant Strains Isolated From Tuberculosis Patients In Iran. Infect Drug Resist. 2019; 12:3437-3444. PMC: 6842285. DOI: 10.2147/IDR.S221823. View

11.

Sahebi L, Ansarin K, Farajnia S, Monfaredan A, Sabour S . Prevalence and risk factors of drug-resistant tuberculosis in border provinces of Iran. Postgrad Med. 2015; 127(6):600-6. DOI: 10.1080/00325481.2015.1069168. View

12.

Miotto P, Zhang Y, Cirillo D, Yam W . Drug resistance mechanisms and drug susceptibility testing for tuberculosis. Respirology. 2018; 23(12):1098-1113. DOI: 10.1111/resp.13393. View

13.

Mohammadi B, Mohajeri P, Rouhi S, Ramazanzadeh R . The relationship between b306 and b406 mutations and ethambutol resistant in isolated from patiens in west of Iran. Med J Islam Repub Iran. 2019; 32:117. PMC: 6387807. DOI: 10.14196/mjiri.32.117. View

14.

Vaziri F, Kohl T, Ghajavand H, Kamakoli M, Merker M, Hadifar S . Genetic Diversity of Multi- and Extensively Drug-Resistant Mycobacterium tuberculosis Isolates in the Capital of Iran, Revealed by Whole-Genome Sequencing. J Clin Microbiol. 2018; 57(1). PMC: 6322472. DOI: 10.1128/JCM.01477-18. View

15.

Liberati A, Altman D, Tetzlaff J, Mulrow C, Gotzsche P, Ioannidis J . The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009; 6(7):e1000100. PMC: 2707010. DOI: 10.1371/journal.pmed.1000100. View

16.

Mohajeri P, Norozi B, Atashi S, Farahani A . Anti tuberculosis drug resistance in west of iran. J Glob Infect Dis. 2014; 6(3):114-7. PMC: 4147420. DOI: 10.4103/0974-777X.138506. View

17.

Ali I, Babak F, Fazlollah M, Nematollah J . Rapid detection of MDR-Mycobacterium tuberculosis using modified PCR-SSCP from clinical Specimens. Asian Pac J Trop Biomed. 2014; 4(Suppl 1):S165-70. PMC: 4025311. DOI: 10.12980/APJTB.4.2014C1186. View

18.

Badie F, Arshadi M, Mohsenpoor M, Gharibvand S . Drug Resistance Pattern of Mycobacterium tuberculosis Isolates From Patients Referred to TB Reference Laboratory in Ahvaz. Osong Public Health Res Perspect. 2016; 7(1):32-5. PMC: 4776274. DOI: 10.1016/j.phrp.2015.10.010. View

19.

Farazi A, Sofian M, Zarrinfar N, Katebi F, Hoseini S, Keshavarz R . Drug resistance pattern and associated risk factors of tuberculosis patients in the central province of Iran. Caspian J Intern Med. 2013; 4(4):785-9. PMC: 3841781. View

20.

Khosravi A, Hashemi Shahraki A, Dezfuli S, Hashemzadeh M, Goodarzi H, Mohajeri P . Genetic diversity of multidrug-resistant Mycobacterium tuberculosis strains isolated from tuberculosis patients in Iran using MIRU-VNTR technique. Kaohsiung J Med Sci. 2017; 33(11):550-557. DOI: 10.1016/j.kjms.2017.06.011. View