Plasma Tetranectin is Reduced in Cancer and Related to Metastasia

Overview

Journal Cancer

Publisher Wiley

Specialty Oncology

Date 1988 Sep 1

PMID 3409168

Citations 15

Authors

B A Jensen

I Clemmensen

Affiliations

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Abstract

Tetranectin, a recently identified and characterized human plasma protein related to the fibrinolytic system, was significantly reduced in patients with various malignancies. Plasma tetranectin, measured by enzyme-linked immunosorbent assay (ELISA), was a significant discriminator regarding metastatic or nonmetastatic cancer. It had a high predictive specificity (0.93) and sensitivity (0.75) and only misclassified 14% of patients. Tetranectin may be related to the pathogenetically important processes leading to cancer spread and metastasis. In this respect, it may prove to be of discriminative importance clinically.

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