Insight into the Function of Tetranectin in Human Diseases: A Review and Prospects for Tetranectin-targeted Disease Treatment

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Jan 8

PMID 38187250

Authors

Sana Iram

Safikur Rahman

Inho Choi

Jihoe Kim

Affiliations

Soon will be listed here.

Abstract

Tetranectin (TN), a serum protein, is closely associated with different types of cancers. TN binds plasminogen and promotes the proteolytic activation of plasminogen into plasmin, which suggests that TN is involved in remodeling the extracellular matrix and cancer tissues during cancer development. TN is also associated with other diseases, such as developmental disorders, cardiovascular diseases, neurological diseases, inflammation, and diabetes. Although the functional mechanism of TN in diseases is not fully elucidated, TN binds different proteins, such as structural protein, a growth factor, and a transcription regulator. Moreover, TN changes and regulates protein functions, indicating that TN-binding proteins mediate the association between TN and diseases. This review summarizes the current knowledge of TN-associated diseases and TN functions with TN-binding proteins in different diseases. In addition, potential TN-targeted disease treatment by inhibiting the interaction between TN and its binding proteins is discussed.

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