Prenatal Exposure to Ambient Air Pollutants and Early Infant Growth and Adiposity in the Southern California Mother's Milk Study

Overview

Journal Environ Health

Publisher Biomed Central

Specialty Environmental Health

Date 2021 Jun 6

PMID 34090448

Citations 19

Authors

William B Patterson

Jessica Glasson

Noopur Naik

Roshonda B Jones

Paige K Berger

Jasmine F Plows

Hilary A Minor

Frederick Lurmann

Michael I Goran

Tanya L Alderete

Affiliations

Soon will be listed here.

Abstract

Background: Prior epidemiological and animal work has linked in utero exposure to ambient air pollutants (AAP) with accelerated postnatal weight gain, which is predictive of increased cardiometabolic risk factors in childhood and adolescence. However, few studies have assessed changes in infant body composition or multiple pollutant exposures. Therefore, the objective of this study was to examine relationships between prenatal residential AAP exposure with infant growth and adiposity.

Methods: Residential exposure to AAP (particulate matter < 2.5 and 10 microns in aerodynamic diameter [PM, PM]; nitrogen dioxide [NO]; ozone [O]; oxidative capacity [O: redox-weighted oxidative potential of O and NO]) was modeled by spatial interpolation of monitoring stations via an inverse distance-squared weighting (IDW2) algorithm for 123 participants from the longitudinal Mother's Milk Study, an ongoing cohort of Hispanic mother-infant dyads from Southern California. Outcomes included changes in infant growth (weight, length), total subcutaneous fat (TSF; calculated via infant skinfold thickness measures) and fat distribution (umbilical circumference, central to total subcutaneous fat [CTSF]) and were calculated by subtracting 1-month measures from 6-month measures. Multivariable linear regression was performed to examine relationships between prenatal AAP exposure and infant outcomes. Models adjusted for maternal age, pre-pregnancy body mass index, socioeconomic status, infant age, sex, and breastfeeding frequency. Sex interactions were tested, and effects are reported for each standard deviation increase in exposure.

Results: NO was associated with greater infant weight gain (β = 0.14, p = 0.02) and TSF (β = 1.69, p = 0.02). PM and PM were associated with change in umbilical circumference (β = 0.73, p = 0.003) and TSF (β = 1.53, p = 0.04), respectively. Associations of O (p < 0.10) with infant length change, umbilical circumference, and CTSF were modified by infant sex. O was associated with attenuated infant length change among males (β = -0.60, p = 0.01), but not females (β = 0.16, p = 0.49); umbilical circumference among females (β = 0.92, p = 0.009), but not males (β = -0.00, p = 0.99); and CTSF among males (β = 0.01, p = 0.03), but not females (β = 0.00, p = 0.51).

Conclusion: Prenatal AAP exposure was associated with increased weight gain and anthropometric measures from 1-to-6 months of life among Hispanic infants. Sex-specific associations suggest differential consequences of in utero oxidative stress. These results indicate that prenatal AAP exposure may alter infant growth, which has potential to increase childhood obesity risk.

Citing Articles

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tRNA-derived RNAs in human milk extracellular vesicles and associations with breastfeeding variables and maternal diet.

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Prenatal ozone exposure is associated with children overweight and obesity: Evidence from the Shanghai Maternal-Child Pairs Cohort.

Sui X, Zhang L, Xu W, Meng X, Zhao Y, Gui Y Eco Environ Health. 2024; 3(4):436-444.

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Prenatal and Early Life Exposure to Ambient Air Pollutants Is Associated with the Fecal Metabolome in the First Two Years of Life.

Holzhausen E, Chalifour B, Tan Y, Young N, Lurmann F, Jones D Environ Sci Technol. 2024; 58(32):14121-14134.

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The joint effects of prenatal exposure to PM constituents and reduced fetal growth on children's accelerated growth in the first 3 years: a birth cohort study.

Zhou S, Li T, Han N, Zhang K, Chen G, Zhang Y J Expo Sci Environ Epidemiol. 2024; .

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References

Saenen N, Martens D, Neven K, Alfano R, Bove H, Janssen B . Air pollution-induced placental alterations: an interplay of oxidative stress, epigenetics, and the aging phenotype?. Clin Epigenetics. 2019; 11(1):124. PMC: 6749657. DOI: 10.1186/s13148-019-0688-z. View

Martens D, Nawrot T . Air Pollution Stress and the Aging Phenotype: The Telomere Connection. Curr Environ Health Rep. 2016; 3(3):258-69. DOI: 10.1007/s40572-016-0098-8. View

Durand C . Does raising type 1 error rate improve power to detect interactions in linear regression models? A simulation study. PLoS One. 2013; 8(8):e71079. PMC: 3745431. DOI: 10.1371/journal.pone.0071079. View

Saenen N, Vrijens K, Janssen B, Roels H, Neven K, Vanden Berghe W . Lower Placental Leptin Promoter Methylation in Association with Fine Particulate Matter Air Pollution during Pregnancy and Placental Nitrosative Stress at Birth in the ENVIRONAGE Cohort. Environ Health Perspect. 2016; 125(2):262-268. PMC: 5289914. DOI: 10.1289/EHP38. View

Bolton J, Smith S, Huff N, Gilmour M, Foster W, Auten R . Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner. FASEB J. 2012; 26(11):4743-54. DOI: 10.1096/fj.12-210989. View

Tessum C, Apte J, Goodkind A, Muller N, Mullins K, Paolella D . Inequity in consumption of goods and services adds to racial-ethnic disparities in air pollution exposure. Proc Natl Acad Sci U S A. 2019; 116(13):6001-6006. PMC: 6442600. DOI: 10.1073/pnas.1818859116. View

Chen M, Liang S, Zhou H, Xu Y, Qin X, Hu Z . Prenatal and postnatal mothering by diesel exhaust PM-exposed dams differentially program mouse energy metabolism. Part Fibre Toxicol. 2017; 14(1):3. PMC: 5423412. DOI: 10.1186/s12989-017-0183-7. View

Rundle A, Hoepner L, Hassoun A, Oberfield S, Freyer G, Holmes D . Association of childhood obesity with maternal exposure to ambient air polycyclic aromatic hydrocarbons during pregnancy. Am J Epidemiol. 2012; 175(11):1163-72. PMC: 3491973. DOI: 10.1093/aje/kwr455. View

Minghetti L, Greco A, Zanardo V, Suppiej A . Early-life sex-dependent vulnerability to oxidative stress: the natural twining model. J Matern Fetal Neonatal Med. 2012; 26(3):259-62. DOI: 10.3109/14767058.2012.733751. View

10.

Bijnens E, Zeegers M, Gielen M, Kicinski M, Hageman G, Pachen D . Lower placental telomere length may be attributed to maternal residential traffic exposure; a twin study. Environ Int. 2015; 79:1-7. DOI: 10.1016/j.envint.2015.02.008. View

11.

Bove H, Bongaerts E, Slenders E, Bijnens E, Saenen N, Gyselaers W . Ambient black carbon particles reach the fetal side of human placenta. Nat Commun. 2019; 10(1):3866. PMC: 6748955. DOI: 10.1038/s41467-019-11654-3. View

12.

Ayer J, Charakida M, Deanfield J, Celermajer D . Lifetime risk: childhood obesity and cardiovascular risk. Eur Heart J. 2015; 36(22):1371-6. DOI: 10.1093/eurheartj/ehv089. View

13.

Lindberg L, Danielsson P, Persson M, Marcus C, Hagman E . Association of childhood obesity with risk of early all-cause and cause-specific mortality: A Swedish prospective cohort study. PLoS Med. 2020; 17(3):e1003078. PMC: 7080224. DOI: 10.1371/journal.pmed.1003078. View

14.

Williams M, Atkinson R, Anderson H, Kelly F . Associations between daily mortality in London and combined oxidant capacity, ozone and nitrogen dioxide. Air Qual Atmos Health. 2014; 7(4):407-414. PMC: 4239710. DOI: 10.1007/s11869-014-0249-8. View

15.

Heindel J, Vandenberg L . Developmental origins of health and disease: a paradigm for understanding disease cause and prevention. Curr Opin Pediatr. 2015; 27(2):248-53. PMC: 4535724. DOI: 10.1097/MOP.0000000000000191. View

16.

Stieb D, Chen L, Eshoul M, Judek S . Ambient air pollution, birth weight and preterm birth: a systematic review and meta-analysis. Environ Res. 2012; 117:100-11. DOI: 10.1016/j.envres.2012.05.007. View

17.

Ananth C, Schisterman E . Confounding, causality, and confusion: the role of intermediate variables in interpreting observational studies in obstetrics. Am J Obstet Gynecol. 2017; 217(2):167-175. PMC: 5545051. DOI: 10.1016/j.ajog.2017.04.016. View

18.

Kannan S, Misra D, Dvonch J, Krishnakumar A . Exposures to airborne particulate matter and adverse perinatal outcomes: a biologically plausible mechanistic framework for exploring potential effect modification by nutrition. Environ Health Perspect. 2006; 114(11):1636-42. PMC: 1665414. DOI: 10.1289/ehp.9081. View

19.

Tsamou M, Vrijens K, Madhloum N, Lefebvre W, Vanpoucke C, Nawrot T . Air pollution-induced placental epigenetic alterations in early life: a candidate miRNA approach. Epigenetics. 2016; 13(2):135-146. PMC: 5873362. DOI: 10.1080/15592294.2016.1155012. View

20.

Pope 3rd C, Burnett R, Turner M, Cohen A, Krewski D, Jerrett M . Lung cancer and cardiovascular disease mortality associated with ambient air pollution and cigarette smoke: shape of the exposure-response relationships. Environ Health Perspect. 2011; 119(11):1616-21. PMC: 3226505. DOI: 10.1289/ehp.1103639. View