Exposures to Airborne Particulate Matter and Adverse Perinatal Outcomes: a Biologically Plausible Mechanistic Framework for Exploring Potential Effect Modification by Nutrition

Overview

Journal Environ Health Perspect

Date 2006 Nov 17

PMID 17107846

Citations 184

Authors

Srimathi Kannan

Dawn P Misra

J Timothy Dvonch

Ambika Krishnakumar

Affiliations

Soon will be listed here.

Abstract

Objectives: The specific objectives are threefold: to describe the biologically plausible mechanistic pathways by which exposure to particulate matter (PM) may lead to the adverse perinatal outcomes of low birth weight (LBW), intrauterine growth retardation (IUGR), and preterm delivery (PTD); review the evidence showing that nutrition affects the biologic pathways; and explain the mechanisms by which nutrition may modify the impact of PM exposure on perinatal outcomes.

Methods: We propose an interdisciplinary conceptual framework that brings together maternal and infant nutrition, air pollution exposure assessment, and cardiopulmonary and perinatal epidemiology. Five possible albeit not exclusive biologic mechanisms have been put forth in the emerging environmental sciences literature and provide corollaries for the proposed framework.

Conclusions: Protecting the environmental health of mothers and infants remains a top global priority. The existing literature indicates that the effects of PM on LBW, PTD, and IUGR may manifest through the cardiovascular mechanisms of oxidative stress, inflammation, coagulation, endothelial function, and hemodynamic responses. PM exposure studies relating mechanistic pathways to perinatal outcomes should consider the likelihood that biologic responses and adverse birth outcomes may be derived from both PM and non-PM sources (e.g., nutrition). In the concluding section, we present strategies for empirically testing the proposed model and developing future research efforts.

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References

Peters A, Doring A, Wichmann H, Koenig W . Increased plasma viscosity during an air pollution episode: a link to mortality?. Lancet. 1997; 349(9065):1582-7. DOI: 10.1016/S0140-6736(97)01211-7. View

Costa D, Dreher K . Bioavailable transition metals in particulate matter mediate cardiopulmonary injury in healthy and compromised animal models. Environ Health Perspect. 1997; 105 Suppl 5:1053-60. PMC: 1470172. DOI: 10.1289/ehp.97105s51053. View

Chen L, Yang W, Jennison B, Goodrich A, Omaye S . Air pollution and birth weight in northern Nevada, 1991-1999. Inhal Toxicol. 2002; 14(2):141-57. DOI: 10.1080/089583701753403962. View

Linn W, Gong Jr H, Clark K, Anderson K . Day-to-day particulate exposures and health changes in Los Angeles area residents with severe lung disease. J Air Waste Manag Assoc. 2000; 49(9):108-15. DOI: 10.1080/10473289.1999.10463890. View

Bobak M . Outdoor air pollution, low birth weight, and prematurity. Environ Health Perspect. 2000; 108(2):173-6. PMC: 1637893. DOI: 10.1289/ehp.00108173. View

Fall C, Yajnik C, Rao S, Davies A, Brown N, Farrant H . Micronutrients and fetal growth. J Nutr. 2003; 133(5 Suppl 2):1747S-1756S. DOI: 10.1093/jn/133.5.1747S. View

Ehrenberg H, Dierker L, Milluzzi C, Mercer B . Low maternal weight, failure to thrive in pregnancy, and adverse pregnancy outcomes. Am J Obstet Gynecol. 2004; 189(6):1726-30. DOI: 10.1016/s0002-9378(03)00860-3. View

Valkonen V, Paiva H, Salonen J, Lakka T, Lehtimaki T, Laakso J . Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine. Lancet. 2002; 358(9299):2127-8. DOI: 10.1016/S0140-6736(01)07184-7. View

Pope 3rd C, Burnett R, Thurston G, Thun M, Calle E, Krewski D . Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation. 2003; 109(1):71-7. DOI: 10.1161/01.CIR.0000108927.80044.7F. View

10.

Ghio A, Cohen M . Disruption of iron homeostasis as a mechanism of biologic effect by ambient air pollution particles. Inhal Toxicol. 2005; 17(13):709-16. DOI: 10.1080/08958370500224482. View

11.

Jansson J, Nilsson T, Johnson O . von Willebrand factor in plasma: a novel risk factor for recurrent myocardial infarction and death. Br Heart J. 1991; 66(5):351-5. PMC: 1024772. DOI: 10.1136/hrt.66.5.351. View

12.

Van Hoydonck P, Temme E, Schouten E . A dietary oxidative balance score of vitamin C, beta-carotene and iron intakes and mortality risk in male smoking Belgians. J Nutr. 2002; 132(4):756-61. DOI: 10.1093/jn/132.4.756. View

13.

Nel A, Diaz-Sanchez D, Ng D, Hiura T, Saxon A . Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system. J Allergy Clin Immunol. 1998; 102(4 Pt 1):539-54. DOI: 10.1016/s0091-6749(98)70269-6. View

14.

Riediker M, Cascio W, Griggs T, Herbst M, Bromberg P, Neas L . Particulate matter exposure in cars is associated with cardiovascular effects in healthy young men. Am J Respir Crit Care Med. 2004; 169(8):934-40. DOI: 10.1164/rccm.200310-1463OC. View

15.

Wilhelm M, Ritz B . Local variations in CO and particulate air pollution and adverse birth outcomes in Los Angeles County, California, USA. Environ Health Perspect. 2005; 113(9):1212-21. PMC: 1280404. DOI: 10.1289/ehp.7751. View

16.

Hennig B, Reiterer G, Majkova Z, Oesterling E, Meerarani P, Toborek M . Modification of environmental toxicity by nutrients: implications in atherosclerosis. Cardiovasc Toxicol. 2005; 5(2):153-60. DOI: 10.1385/ct:5:2:153. View

17.

Ibald-Mulli A, Timonen K, Peters A, Heinrich J, Wolke G, Lanki T . Effects of particulate air pollution on blood pressure and heart rate in subjects with cardiovascular disease: a multicenter approach. Environ Health Perspect. 2004; 112(3):369-77. PMC: 1241869. DOI: 10.1289/ehp.6523. View

18.

Vollset S, Refsum H, Irgens L, Emblem B, Tverdal A, Gjessing H . Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study. Am J Clin Nutr. 2000; 71(4):962-8. DOI: 10.1093/ajcn/71.4.962. View

19.

Porrini M, Riso P, Oriani G . Spinach and tomato consumption increases lymphocyte DNA resistance to oxidative stress but this is not related to cell carotenoid concentrations. Eur J Nutr. 2002; 41(3):95-100. DOI: 10.1007/s003940200014. View

20.

Ostro B, Broadwin R, Green S, Feng W, Lipsett M . Fine particulate air pollution and mortality in nine California counties: results from CALFINE. Environ Health Perspect. 2006; 114(1):29-33. PMC: 1332652. DOI: 10.1289/ehp.8335. View