Thyroid Hormone Regulates Abrupt Skin Morphogenesis During Zebrafish Postembryonic Development

Overview

Journal Dev Biol

Publisher Elsevier

Specialties Biology
Reproductive Medicine

Date 2021 Jun 5

PMID 34089732

Citations 8

Authors

Andrew J Aman

Margaret Kim

Lauren M Saunders

David M Parichy

Affiliations

Soon will be listed here.

Abstract

Thyroid hormone is a key regulator of post-embryonic vertebrate development. Skin is a biomedically important thyroid hormone target organ, but the cellular and molecular mechanisms underlying skin pathologies associated with thyroid dysfunction remain obscure. The transparent skin of zebrafish is an accessible model system for studying vertebrate skin development. During post-embryonic development of the zebrafish, scales emerge in the skin from a hexagonally patterned array of dermal papillae, like other vertebrate skin appendages such as feathers and hair follicles. We show here that thyroid hormone regulates the rate of post-embryonic dermal development through interaction with nuclear hormone receptors. This couples skin development with body growth to generate a well ordered array of correctly proportioned scales. This work extends our knowledge of thyroid hormone actions on skin by providing in-vivo evidence that thyroid hormone regulates multiple aspects of dermal development.

Citing Articles

Experimentally Manipulating the Thyroid Hormone Axis in Zebrafish.

Autumn M, Zeng J, Ranieri I, McMenamin S Methods Mol Biol. 2024; 2876:189-198.

PMID: 39579317 DOI: 10.1007/978-1-0716-4252-8_13.

foxe1 mutant zebrafish show indications of a hypothyroid phenotype and increased sensitivity to ethanol for craniofacial malformations.

Raterman S, Wagener F, Zethof J, Cuijpers V, Klaren P, Metz J Dev Dyn. 2024; 254(3):240-256.

PMID: 39360443 PMC: 11877993. DOI: 10.1002/dvdy.745.

Anatomy, development and regeneration of zebrafish elasmoid scales.

Aman A, Parichy D Dev Biol. 2024; 510:1-7.

PMID: 38458375 PMC: 11015963. DOI: 10.1016/j.ydbio.2024.03.001.

An active traveling wave of Eda/NF-κB signaling controls the timing and hexagonal pattern of skin appendages in zebrafish.

Evanitsky M, Di Talia S Development. 2023; 150(18).

PMID: 37747266 PMC: 10560567. DOI: 10.1242/dev.201866.

Transcriptomic profiling of tissue environments critical for post-embryonic patterning and morphogenesis of zebrafish skin.

Aman A, Saunders L, Carr A, Srivatasan S, Eberhard C, Carrington B Elife. 2023; 12.

PMID: 37695017 PMC: 10495112. DOI: 10.7554/eLife.86670.

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