» Articles » PMID: 34079762

MiR-1258 Attenuates Tumorigenesis Through Targeting E2F1 to Inhibit and Transcription in Glioblastoma

Overview
Journal Front Oncol
Specialty Oncology
Date 2021 Jun 3
PMID 34079762
Citations 6
Authors
Affiliations
Soon will be listed here.
Abstract

MicroRNAs are a group of endogenous small non-coding RNAs commonly dysregulated in tumorigenesis, including glioblastoma (GBM), the most malignant brain tumor with rapid proliferation, diffuse invasion, and therapeutic resistance. Accumulating evidence has manifested that miR-1258 exerts an inhibitory role in many human cancers. However, the expression pattern of miR-1258 and its potential function in GBM tumorigenesis remain unclear. In this study, we reported that miR-1258 expression decreased with the ascending pathological grade of glioma, which indicated an unfavorable prognosis of patients. Functional assays revealed an inhibitory effect of miR-1258 on malignant proliferation, therapeutic resistance, migration, and invasion of GBM . Moreover, xenograft models also suggested a repression effect of miR-1258 on gliomagenesis. Mechanistically, miR-1258 directly targeted E2F1 in 3'-untranslated regions and attenuated E2F1-mediated downstream gene and transcriptions. Furthermore, restoration of E2F1 expression in GBM cells effectively rescued the tumor-suppressive effect of miR-1258. Our studies illustrated that miR-1258 functioned as a tumor suppressor in GBM by directly targeting E2F1, subsequently inhibiting and transcriptions, which contributed to new potential targets for GBM therapy and other E2F1-driven cancers.

Citing Articles

Glioma-astrocyte connexin43 confers temozolomide resistance through activation of the E2F1/ERCC1 axis.

Gui Y, Qin H, Zhang X, Chen Q, Ye F, Tian G Neuro Oncol. 2024; 27(3):711-726.

PMID: 39514365 PMC: 11889727. DOI: 10.1093/neuonc/noae237.


Role of Non-coding RNAs in the Response of Glioblastoma to Temozolomide.

Goleij P, Pourali G, Raisi A, Ravaei F, Golestan S, Abed A Mol Neurobiol. 2024; 62(2):1726-1755.

PMID: 39023794 DOI: 10.1007/s12035-024-04316-z.


Systematic characterization and biological functions of non-coding RNAs in glioblastoma.

Dai L, Liang W, Shi Z, Li X, Zhou S, Hu W Cell Prolif. 2022; 56(3):e13375.

PMID: 36457281 PMC: 9977673. DOI: 10.1111/cpr.13375.


Research progress on microRNA-1258 in the development of human cancer.

Qian M, Xia Y, Zhang G, Yu H, Cui Y Front Oncol. 2022; 12:1024234.

PMID: 36249037 PMC: 9556982. DOI: 10.3389/fonc.2022.1024234.


MicroRNA-147a Targets SLC40A1 to Induce Ferroptosis in Human Glioblastoma.

Xu P, Ge F, Li W, Xu Z, Wang X, Shen J Anal Cell Pathol (Amst). 2022; 2022:2843990.

PMID: 35942174 PMC: 9356897. DOI: 10.1155/2022/2843990.


References
1.
Liu F, Zhang Q, Liang Y . MicroRNA-598 acts as an inhibitor in retinoblastoma through targeting E2F1 and regulating AKT pathway. J Cell Biochem. 2019; 121(3):2294-2302. DOI: 10.1002/jcb.29453. View

2.
Zhi T, Jiang K, Xu X, Yu T, Zhou F, Wang Y . ECT2/PSMD14/PTTG1 axis promotes the proliferation of glioma through stabilizing E2F1. Neuro Oncol. 2018; 21(4):462-473. PMC: 6422441. DOI: 10.1093/neuonc/noy207. View

3.
Liu W, Zhou Z, Zhang Q, Rong Y, Li L, Luo Y . Overexpression of miR-1258 inhibits cell proliferation by targeting AKT3 in osteosarcoma. Biochem Biophys Res Commun. 2019; 510(3):479-486. DOI: 10.1016/j.bbrc.2019.01.139. View

4.
Tan A, Ashley D, Lopez G, Malinzak M, Friedman H, Khasraw M . Management of glioblastoma: State of the art and future directions. CA Cancer J Clin. 2020; 70(4):299-312. DOI: 10.3322/caac.21613. View

5.
Engelmann D, Putzer B . The dark side of E2F1: in transit beyond apoptosis. Cancer Res. 2012; 72(3):571-5. DOI: 10.1158/0008-5472.CAN-11-2575. View