Non-Coding RNAs in Glioma

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2018 Dec 26

PMID 30583549

Citations 79

Authors

Ryte Rynkeviciene

Julija Simiene

Egle Strainiene

Vaidotas Stankevicius

Jurgita Usinskiene

Edita Miseikyte Kaubriene

Ingrida Meskinyte

Jonas Cicenas

Kestutis Suziedelis

Affiliations

Soon will be listed here.

Abstract

Glioma is the most aggressive brain tumor of the central nervous system. The ability of glioma cells to migrate, rapidly diffuse and invade normal adjacent tissue, their sustained proliferation, and heterogeneity contribute to an overall survival of approximately 15 months for most patients with high grade glioma. Numerous studies indicate that non-coding RNA species have critical functions across biological processes that regulate glioma initiation and progression. Recently, new data emerged, which shows that the cross-regulation between long non-coding RNAs and small non-coding RNAs contribute to phenotypic diversity of glioblastoma subclasses. In this paper, we review data of long non-coding RNA expression, which was evaluated in human glioma tissue samples during a five-year period. Thus, this review summarizes the following: (I) the role of non-coding RNAs in glioblastoma pathogenesis, (II) the potential application of non-coding RNA species in glioma-grading, (III) crosstalk between lncRNAs and miRNAs (IV) future perspectives of non-coding RNAs as biomarkers for glioma.

Citing Articles

The role of lncRNAs in the interplay of signaling pathways and epigenetic mechanisms in glioma.

Bora Yildiz C, Du J, Mohan K, Zimmer-Bensch G, Abdolahi S Epigenomics. 2025; 17(2):125-140.

PMID: 39829063 PMC: 11792803. DOI: 10.1080/17501911.2024.2442297.

Bibliometric and visualization analysis in the field of epigenetics and glioma (2009-2024).

Zeng Y, Tao G, Zeng Y, He J, Cao H, Zhang L Front Oncol. 2024; 14:1431636.

PMID: 39534093 PMC: 11555291. DOI: 10.3389/fonc.2024.1431636.

The landscape of circRNAs in gliomas temozolomide resistance: Insights into molecular pathways.

Mafi A, Hedayati N, Kahkesh S, Khoshayand S, Alimohammadi M, Farahani N Noncoding RNA Res. 2024; 9(4):1178-1189.

PMID: 39022676 PMC: 11250881. DOI: 10.1016/j.ncrna.2024.05.010.

The pathogenesis mechanism and potential clinical value of lncRNA in gliomas.

Liu Y, Yuan H, Fan J, Wang H, Xie H, Wan J Discov Oncol. 2024; 15(1):266.

PMID: 38967893 PMC: 11226588. DOI: 10.1007/s12672-024-01144-4.

Long non-coding RNA MEG3 knockdown represses airway smooth muscle cells proliferation and migration via sponging miR-143-3p/FGF9 in asthma.

Gu J, Zhou D J Cardiothorac Surg. 2024; 19(1):314.

PMID: 38824534 PMC: 11143653. DOI: 10.1186/s13019-024-02798-5.

References

Lander E, Linton L, Birren B, Nusbaum C, Zody M, Baldwin J . Initial sequencing and analysis of the human genome. Nature. 2001; 409(6822):860-921. DOI: 10.1038/35057062. View

De Sanctis V, Mazzarella G, Osti M, Valeriani M, Alfo M, Salvati M . Radiotherapy and sequential temozolomide compared with radiotherapy with concomitant and sequential temozolomide in the treatment of newly diagnosed glioblastoma multiforme. Anticancer Drugs. 2006; 17(8):969-75. DOI: 10.1097/01.cad.0000224446.31577.df. View

Jain R, Tomaso E, Duda D, Loeffler J, Sorensen A, Batchelor T . Angiogenesis in brain tumours. Nat Rev Neurosci. 2007; 8(8):610-22. DOI: 10.1038/nrn2175. View

Lungu G, Covaleda L, Mendes O, Martini-Stoica H, Stoica G . FGF-1-induced matrix metalloproteinase-9 expression in breast cancer cells is mediated by increased activities of NF-kappaB and activating protein-1. Mol Carcinog. 2007; 47(6):424-35. DOI: 10.1002/mc.20398. View

Farazi T, Juranek S, Tuschl T . The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members. Development. 2008; 135(7):1201-14. DOI: 10.1242/dev.005629. View

Tam O, Aravin A, Stein P, Girard A, Murchison E, Cheloufi S . Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature. 2008; 453(7194):534-8. PMC: 2981145. DOI: 10.1038/nature06904. View

Papagiannakopoulos T, Shapiro A, Kosik K . MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Res. 2008; 68(19):8164-72. DOI: 10.1158/0008-5472.CAN-08-1305. View

Fischbach C, Kong H, Hsiong S, Evangelista M, Yuen W, Mooney D . Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement. Proc Natl Acad Sci U S A. 2009; 106(2):399-404. PMC: 2626714. DOI: 10.1073/pnas.0808932106. View

. Post-transcriptional processing generates a diversity of 5'-modified long and short RNAs. Nature. 2009; 457(7232):1028-32. PMC: 2719882. DOI: 10.1038/nature07759. View

10.

Wilusz J, Sunwoo H, Spector D . Long noncoding RNAs: functional surprises from the RNA world. Genes Dev. 2009; 23(13):1494-504. PMC: 3152381. DOI: 10.1101/gad.1800909. View

11.

Hu G, Wei Y, Kang Y . The multifaceted role of MTDH/AEG-1 in cancer progression. Clin Cancer Res. 2009; 15(18):5615-20. PMC: 2747034. DOI: 10.1158/1078-0432.CCR-09-0049. View

12.

Kim H, Huang W, Jiang X, Pennicooke B, Park P, Johnson M . Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship. Proc Natl Acad Sci U S A. 2010; 107(5):2183-8. PMC: 2836668. DOI: 10.1073/pnas.0909896107. View

13.

Hanahan D, Weinberg R . Hallmarks of cancer: the next generation. Cell. 2011; 144(5):646-74. DOI: 10.1016/j.cell.2011.02.013. View

14.

Roth P, Wischhusen J, Happold C, Chandran P, Hofer S, Eisele G . A specific miRNA signature in the peripheral blood of glioblastoma patients. J Neurochem. 2011; 118(3):449-57. DOI: 10.1111/j.1471-4159.2011.07307.x. View

15.

Foster D, Yellen P, Xu L, Saqcena M . Regulation of G1 Cell Cycle Progression: Distinguishing the Restriction Point from a Nutrient-Sensing Cell Growth Checkpoint(s). Genes Cancer. 2011; 1(11):1124-31. PMC: 3092273. DOI: 10.1177/1947601910392989. View

16.

Yang C, Yue J, Pfeffer S, Handorf C, Pfeffer L . MicroRNA miR-21 regulates the metastatic behavior of B16 melanoma cells. J Biol Chem. 2011; 286(45):39172-8. PMC: 3234742. DOI: 10.1074/jbc.M111.285098. View

17.

Wang X, Shi Z, Wang X, Cao L, Wang Y, Zhang J . MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2. J Cancer Res Clin Oncol. 2011; 138(4):573-84. DOI: 10.1007/s00432-011-1114-x. View

18.

Crocetti E, Trama A, Stiller C, Caldarella A, Soffietti R, Jaal J . Epidemiology of glial and non-glial brain tumours in Europe. Eur J Cancer. 2012; 48(10):1532-42. DOI: 10.1016/j.ejca.2011.12.013. View

19.

Lu Y, Zhang K, Li C, Yao Y, Tao D, Liu Y . Piwil2 suppresses p53 by inducing phosphorylation of signal transducer and activator of transcription 3 in tumor cells. PLoS One. 2012; 7(1):e30999. PMC: 3267750. DOI: 10.1371/journal.pone.0030999. View

20.

Cooper L, Gutman D, Chisolm C, Appin C, Kong J, Rong Y . The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma. Am J Pathol. 2012; 180(5):2108-19. PMC: 3354586. DOI: 10.1016/j.ajpath.2012.01.040. View