The Natural Analgesic Conolidine Targets the Newly Identified Opioid Scavenger ACKR3/CXCR7

Overview

Journal Signal Transduct Target Ther

Specialties Cell Biology
Pharmacology

Date 2021 Jun 2

PMID 34075018

Citations 9

Authors

Martyna Szpakowska

Ann M Decker

Max Meyrath

Christie B Palmer

Bruce E Blough

Ojas A Namjoshi

Andy Chevigne

Affiliations

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References

Tarselli M, Raehal K, Brasher A, Streicher J, Groer C, Cameron M . Synthesis of conolidine, a potent non-opioid analgesic for tonic and persistent pain. Nat Chem. 2011; 3(6):449-53. DOI: 10.1038/nchem.1050. View

Ikeda Y, Kumagai H, Skach A, Sato M, Yanagisawa M . Modulation of circadian glucocorticoid oscillation via adrenal opioid-CXCR7 signaling alters emotional behavior. Cell. 2013; 155(6):1323-36. PMC: 3934808. DOI: 10.1016/j.cell.2013.10.052. View

Gillis A, Gondin A, Kliewer A, Sanchez J, Lim H, Alamein C . Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists. Sci Signal. 2020; 13(625). DOI: 10.1126/scisignal.aaz3140. View

Meyrath M, Szpakowska M, Zeiner J, Massotte L, Merz M, Benkel T . The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides. Nat Commun. 2020; 11(1):3033. PMC: 7305236. DOI: 10.1038/s41467-020-16664-0. View