Aging-Related Metabolic Dysfunction in the Salivary Gland: A Review of the Literature

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Jun 2

PMID 34072470

Citations 23

Authors

Nguyen Khanh Toan

Sang-Gun Ahn

Affiliations

Soon will be listed here.

Abstract

Aging-related salivary dysfunction commonly induces the poor oral health, including decreased saliva flow and dental caries. Although the clinical significance of the salivary glands is well-known, the complex metabolic pathways contributing to the aging-dysfunction process are only beginning to be uncovered. Here, we provide a comprehensive overview of the metabolic changes in aging-mediated salivary gland dysfunction as a key aspect of oral physiology. Several metabolic neuropeptides or hormones are involved in causing or contributing to salivary gland dysfunction, including hyposalivation and age-related diseases. Thus, aging-related metabolism holds promise for early diagnosis, increased choice of therapy and the identification of new metabolic pathways that could potentially be targeted in salivary gland dysfunction.

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References

Slomiany B, MURTY V, Piotrowski J, Slomiany A . Salivary mucins in oral mucosal defense. Gen Pharmacol. 1996; 27(5):761-71. DOI: 10.1016/0306-3623(95)02050-0. View

Proulx M, de Courval F, Wiseman M, Panisset M . Salivary production in Parkinson's disease. Mov Disord. 2004; 20(2):204-7. DOI: 10.1002/mds.20189. View

Kurabuchi S, Hosoi K . Immunocytochemical study of granular duct cells with a hormonally enhanced granular cell phenotype in the mouse parotid gland. Odontology. 2009; 97(1):57-61. DOI: 10.1007/s10266-008-0090-3. View

SREEBNY L, Schwartz S . A reference guide to drugs and dry mouth--2nd edition. Gerodontology. 1997; 14(1):33-47. DOI: 10.1111/j.1741-2358.1997.00033.x. View

Proctor G, Carpenter G . Regulation of salivary gland function by autonomic nerves. Auton Neurosci. 2006; 133(1):3-18. DOI: 10.1016/j.autneu.2006.10.006. View

Mata A, Marques D, Rocha S, Francisco H, Santos C, Mesquita M . Effects of diabetes mellitus on salivary secretion and its composition in the human. Mol Cell Biochem. 2004; 261(1-2):137-42. DOI: 10.1023/b:mcbi.0000028748.40917.6f. View

Haas H, Sergeeva O, Selbach O . Histamine in the nervous system. Physiol Rev. 2008; 88(3):1183-241. DOI: 10.1152/physrev.00043.2007. View

Hasin Y, Seldin M, Lusis A . Multi-omics approaches to disease. Genome Biol. 2017; 18(1):83. PMC: 5418815. DOI: 10.1186/s13059-017-1215-1. View

Kageyama G, Saegusa J, Irino Y, Tanaka S, Tsuda K, Takahashi S . Metabolomics analysis of saliva from patients with primary Sjögren's syndrome. Clin Exp Immunol. 2015; 182(2):149-53. PMC: 4608504. DOI: 10.1111/cei.12683. View

10.

Egea J, Hirtz C, Gross R, Lajoix A, Traskawka E, Ribes G . Preproinsulin I and II mRNA expression in adult rat submandibular glands. Eur J Oral Sci. 2000; 108(4):292-6. DOI: 10.1034/j.1600-0722.2000.108004292.x. View

11.

Boison D, Shen H . Adenosine kinase is a new therapeutic target to prevent ischemic neuronal death. Open Drug Discov J. 2013; 2(3):108-118. PMC: 3786597. View

12.

Chang W, Chang J, Kim Y, Lee G, Kho H . MUC1 expression in the oral mucosal epithelial cells of the elderly. Arch Oral Biol. 2011; 56(9):885-90. DOI: 10.1016/j.archoralbio.2011.02.007. View

13.

Lohavanichbutr P, Zhang Y, Wang P, Gu H, Gowda G, Djukovic D . Salivary metabolite profiling distinguishes patients with oral cavity squamous cell carcinoma from normal controls. PLoS One. 2018; 13(9):e0204249. PMC: 6147497. DOI: 10.1371/journal.pone.0204249. View

14.

Hasko G, Pacher P . Regulation of macrophage function by adenosine. Arterioscler Thromb Vasc Biol. 2012; 32(4):865-9. PMC: 3387535. DOI: 10.1161/ATVBAHA.111.226852. View

15.

Noaiseh G, Baker J, Vivino F . Comparison of the discontinuation rates and side-effect profiles of pilocarpine and cevimeline for xerostomia in primary Sjögren's syndrome. Clin Exp Rheumatol. 2014; 32(4):575-7. View

16.

Andersson M, Aman P, Stenman G . IGF2/IGF1R Signaling as a Therapeutic Target in MYB-Positive Adenoid Cystic Carcinomas and Other Fusion Gene-Driven Tumors. Cells. 2019; 8(8). PMC: 6721700. DOI: 10.3390/cells8080913. View

17.

Rocchi C, Emmerson E . Mouth-Watering Results: Clinical Need, Current Approaches, and Future Directions for Salivary Gland Regeneration. Trends Mol Med. 2020; 26(7):649-669. DOI: 10.1016/j.molmed.2020.03.009. View

18.

Colella G, Izzo G, Carinci F, Campisi G, Lo Muzio L, DAmato S . Expression of sexual hormones receptors in oral squamous cell carcinoma. Int J Immunopathol Pharmacol. 2011; 24(2 Suppl):129-32. DOI: 10.1177/03946320110240S222. View

19.

Baquero A, Gilbertson T . Insulin activates epithelial sodium channel (ENaC) via phosphoinositide 3-kinase in mammalian taste receptor cells. Am J Physiol Cell Physiol. 2010; 300(4):C860-71. PMC: 3074626. DOI: 10.1152/ajpcell.00318.2010. View

20.

Sumida T, Ishikawa A, Kamata Y, Nakano H, Yamada T, Mori Y . Estrogen Enhances Malignant Phenotypes in Human Salivary Adenoid Cystic Carcinoma Cells. Anticancer Res. 2016; 36(6):2793-8. View