The Preparation and Characterization of Chitosan-Based Hydrogels Cross-Linked by Glyoxal

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2021 Jun 2

PMID 34065063

Citations 12

Authors

Beata Kaczmarek-Szczepanska

Olha Mazur

Marta Michalska-Sionkowska

Krzysztof Lukowicz

Anna Maria Osyczka

Affiliations

Soon will be listed here.

Abstract

In this study, hydrogels based on chitosan cross-linked by glyoxal have been investigated for potential medical applications. Hydrogels were loaded with tannic acid at different concentrations. The thermal stability and the polyphenol-releasing rate were determined. For a preliminary assessment of the clinical usefulness of the hydrogels, they were examined for blood compatibility and in the culture of human dental pulp cells (hDPC). The results showed that after immersion in a polyphenol solution, chitosan/glyoxal hydrogels remain nonhemolytic for erythrocytes, and we also did not observe the cytotoxic effect of hydrogels immersed in tannic acid (TA) solutions with different concentration. Tannic acid was successfully released from hydrogels, and its addition improved material thermal stability. Thus, the current findings open the possibility to consider such hydrogels in clinics.

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