Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike's Dynamics

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2021 Jun 2

PMID 34064904

Citations 6

Authors

Jorge Gonzalez-Puelma

Jacqueline Aldridge

Marco Montes de Oca

Monica Pinto

Roberto Uribe-Paredes

Jose Fernandez-Goycoolea

Diego Alvarez-Saravia

Hermy Alvarez

Gonzalo Encina

Thomas Weitzel

Rodrigo Munoz

Alvaro Olivera-Nappa

Sergio Pantano

Marcelo A Navarrete

Affiliations

Soon will be listed here.

Abstract

The emergence of SARS-CoV-2 variants, as observed with the D614G spike protein mutant and, more recently, with B.1.1.7 (501Y.V1), B.1.351 (501Y.V2) and B.1.1.28.1 (P.1) lineages, represent a continuous threat and might lead to strains of higher infectivity and/or virulence. We report on the occurrence of a SARS-CoV-2 haplotype with nine mutations including D614G/T307I double-mutation of the spike. This variant expanded and completely replaced previous lineages within a short period in the subantarctic Magallanes Region, southern Chile. The rapid lineage shift was accompanied by a significant increase of cases, resulting in one of the highest incidence rates worldwide. Comparative coarse-grained molecular dynamic simulations indicated that T307I and D614G belong to a previously unrecognized dynamic domain, interfering with the mobility of the receptor binding domain of the spike. The T307I mutation showed a synergistic effect with the D614G. Continuous surveillance of new mutations and molecular analyses of such variations are important tools to understand the molecular mechanisms defining infectivity and virulence of current and future SARS-CoV-2 strains.

Citing Articles

Early mutational signatures and transmissibility of SARS-CoV-2 Gamma and Lambda variants in Chile.

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