The Role of MRI in Cervical Cancer > 2 cm (FIGO Stage IB2-IIA1) Conservatively Treated with Neoadjuvant Chemotherapy Followed by Conization: a Pilot Study

Overview

Journal Radiol Med

Specialty Radiology

Date 2021 Jun 1

PMID 34060027

Citations 8

Authors

Luca Russo

Benedetta Gui

Maura Micco

Camilla Panico

Rosa De Vincenzo

Francesco Fanfani

Giovanni Scambia

Riccardo Manfredi

Affiliations

Soon will be listed here.

Abstract

Introduction: MRI is very accurate in selecting young women with cervical cancer for fertility-sparing surgery (FSS), in particular radical hysterectomy (RH). In order to improve obstetrical outcomes, neoadjuvant chemotherapy (NACT) followed by cold knife conization (CKC) has been proposed as alternative technique.

Objective: To investigate the role of MRI in evaluation of response to treatment after neoadjuvant chemotherapy (NACT), followed by CKC, in patients with cervical cancer FIGO stage IB2-IIA1 with tumor size 2 - 4 cm, desiring to preserve their fertility.

Methods: 13 young women (23-36 years old) with cervical cancer stage IB2-IIA1 desiring to preserve their fertility were included. Tumor diameter at baseline and after treatment was detected on 1.5 T MRI. Treatment response was assessed according to Response Evaluation Criteria in Solid Tumors (RECIST 1.1) and then compared to histopathology result.

Results: MRI correctly assessed 11 out of 13 cases, according to RECIST 1.1, compared to histopathology. Among these 7 patients with partial response (PR), 2 cases of CR, 1 SD and 1 PD with persistence or enlargement of primary tumor.

Conclusion: Our pilot study supports the usefulness of MRI in assessment of treatment response after NACT, followed by CKC.

Trial Registration Number: ClinicalTrials.gov: NCT02323841.

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