Risky Family Climates Presage Increased Cellular Aging in Young Adulthood

Overview

Journal Psychoneuroendocrinology

Specialties Endocrinology
Neurology
Psychiatry

Date 2021 May 31

PMID 34058561

Citations 6

Authors

Gene H Brody

Tianyi Yu

Edith Chen

Michael Kobor

Steven R H Beach

Man-Kit Lei

Ashley Barr

David Tse-Shen Lin

Gregory E Miller

Affiliations

Soon will be listed here.

Abstract

A scientific consensus is emerging that children reared in risky family climates are prone to chronic diseases and premature death later in life. Few prospective data, however, are available to inform the mechanisms of these relationships. In a prospective study involving 323 Black families, we sought to determine whether, and how, childhood risky family climates are linked to a potential risk factor for later-life disease: increases in cellular aging (indexed by epigenetic aging). As hypothesized, risky family climates were associated with greater outflows of the stress hormones epinephrine and norepinephrine at ages 19 and 20 years; this, in turn, led to increases in cellular aging across ages 20-27 years. If sustained, these tendencies may place children from risky family climates on a trajectory toward the chronic diseases of aging.

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