Supportive Family Environments Ameliorate the Link Between Racial Discrimination and Epigenetic Aging: A Replication Across Two Longitudinal Cohorts

Overview

Journal Psychol Sci

Specialty Psychology

Date 2016 Feb 27

PMID 26917213

Citations 99

Authors

Gene H Brody

Gregory E Miller

Tianyi Yu

Steven R H Beach

Edith Chen

Affiliations

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Abstract

This study tested the hypothesis that supportive family environments during adolescence buffer exposure to racial discrimination, reducing its impact on biological weathering and its manifestation in cellular aging. Perceived racial discrimination, support in the family environment, and confounder variables were assessed for 3 consecutive years across adolescence in two independent cohorts of African American youth from rural Georgia. DNA was extracted from peripheral blood mononuclear cells collected during young adulthood. Patterns of methylation were used to index the epigenetic ages of these cells and the extent to which they differed from participants' chronological ages. Among youth in supportive family environments, exposure to higher levels of racial discrimination did not forecast greater epigenetic aging. Among youth in less supportive family environments, exposure to higher levels of racial discrimination did forecast greater epigenetic aging. The associations emerged independently of confounder variables, and the results were replicated across the two cohorts.

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References

Miller G, Lachman M, Chen E, Gruenewald T, Karlamangla A, Seeman T . Pathways to resilience: maternal nurturance as a buffer against the effects of childhood poverty on metabolic syndrome at midlife. Psychol Sci. 2011; 22(12):1591-9. PMC: 3362047. DOI: 10.1177/0956797611419170. View

Pascoe E, Richman L . Perceived discrimination and health: a meta-analytic review. Psychol Bull. 2009; 135(4):531-54. PMC: 2747726. DOI: 10.1037/a0016059. View

Brody G, Kogan S, Chen Y . Perceived discrimination and longitudinal increases in adolescent substance use: gender differences and mediational pathways. Am J Public Health. 2012; 102(5):1006-11. PMC: 3325367. DOI: 10.2105/AJPH.2011.300588. View

Chen E, Miller G, Kobor M, Cole S . Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signaling in adulthood. Mol Psychiatry. 2010; 16(7):729-37. PMC: 2925055. DOI: 10.1038/mp.2010.53. View

Marioni R, Shah S, McRae A, Chen B, Colicino E, Harris S . DNA methylation age of blood predicts all-cause mortality in later life. Genome Biol. 2015; 16:25. PMC: 4350614. DOI: 10.1186/s13059-015-0584-6. View

Evans G . A multimethodological analysis of cumulative risk and allostatic load among rural children. Dev Psychol. 2003; 39(5):924-33. DOI: 10.1037/0012-1649.39.5.924. View

Lewis T, Cogburn C, Williams D . Self-reported experiences of discrimination and health: scientific advances, ongoing controversies, and emerging issues. Annu Rev Clin Psychol. 2015; 11:407-40. PMC: 5555118. DOI: 10.1146/annurev-clinpsy-032814-112728. View

Shen B, Countryman A, Spiro 3rd A, Niaura R . The prospective contribution of hostility characteristics to high fasting glucose levels: the moderating role of marital status. Diabetes Care. 2008; 31(7):1293-8. PMC: 2453669. DOI: 10.2337/dc07-1945. View

Brody G, Lei M, Chae D, Yu T, Kogan S, Beach S . Perceived discrimination among African American adolescents and allostatic load: a longitudinal analysis with buffering effects. Child Dev. 2014; 85(3):989-1002. PMC: 4019687. DOI: 10.1111/cdev.12213. View

10.

Brody G, Chen Y, Kogan S . A cascade model connecting life stress to risk behavior among rural African American emerging adults. Dev Psychopathol. 2010; 22(3):667-78. PMC: 2902871. DOI: 10.1017/S0954579410000350. View

11.

Carroll J, Gruenewald T, Taylor S, Janicki-Deverts D, Matthews K, Seeman T . Childhood abuse, parental warmth, and adult multisystem biological risk in the Coronary Artery Risk Development in Young Adults study. Proc Natl Acad Sci U S A. 2013; 110(42):17149-53. PMC: 3800991. DOI: 10.1073/pnas.1315458110. View

12.

Barnes P, Adcock I . Glucocorticoid resistance in inflammatory diseases. Lancet. 2009; 373(9678):1905-17. DOI: 10.1016/S0140-6736(09)60326-3. View

13.

Wills T, Vaccaro D, McNamara G . The role of life events, family support, and competence in adolescent substance use: a test of vulnerability and protective factors. Am J Community Psychol. 1992; 20(3):349-74. DOI: 10.1007/BF00937914. View

14.

Smith-Bynum M, Lambert S, English D, Ialongo N . Associations between trajectories of perceived racial discrimination and psychological symptoms among African American adolescents. Dev Psychopathol. 2014; 26(4 Pt 1):1049-65. PMC: 4205197. DOI: 10.1017/S0954579414000571. View

15.

Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda S . Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell. 2012; 49(2):359-367. PMC: 3780611. DOI: 10.1016/j.molcel.2012.10.016. View

16.

Greene M, Way N, Pahl K . Trajectories of perceived adult and peer discrimination among Black, Latino, and Asian American adolescents: patterns and psychological correlates. Dev Psychol. 2006; 42(2):218-36. DOI: 10.1037/0012-1649.42.2.218. View

17.

Carver C, Scheier M, Weintraub J . Assessing coping strategies: a theoretically based approach. J Pers Soc Psychol. 1989; 56(2):267-83. DOI: 10.1037//0022-3514.56.2.267. View

18.

Fredrickson B, Maynard K, Helms M, Haney T, Siegler I, Barefoot J . Hostility predicts magnitude and duration of blood pressure response to anger. J Behav Med. 2000; 23(3):229-43. DOI: 10.1023/a:1005596208324. View

19.

Schuster M, Elliott M, Kanouse D, Wallander J, Tortolero S, Ratner J . Racial and ethnic health disparities among fifth-graders in three cities. N Engl J Med. 2012; 367(8):735-45. DOI: 10.1056/NEJMsa1114353. View

20.

Morris A, Silk J, Steinberg L, Myers S, Robinson L . The Role of the Family Context in the Development of Emotion Regulation. Soc Dev. 2009; 16(2):361-388. PMC: 2743505. DOI: 10.1111/j.1467-9507.2007.00389.x. View