Oxidative Stress in Bacteria and the Central Dogma of Molecular Biology

Overview

Journal Front Mol Biosci

Specialty Biology

Date 2021 May 27

PMID 34041267

Citations 70

Authors

Michel Fasnacht

Norbert Polacek

Affiliations

Soon will be listed here.

Abstract

Ever since the "great oxidation event," Earth's cellular life forms had to cope with the danger of reactive oxygen species (ROS) affecting the integrity of biomolecules and hampering cellular metabolism circuits. Consequently, increasing ROS levels in the biosphere represented growing stress levels and thus shaped the evolution of species. Whether the ROS were produced endogenously or exogenously, different systems evolved to remove the ROS and repair the damage they inflicted. If ROS outweigh the cell's capacity to remove the threat, we speak of oxidative stress. The injuries through oxidative stress in cells are diverse. This article reviews the damage oxidative stress imposes on the different steps of the central dogma of molecular biology in bacteria, focusing in particular on the RNA machines involved in transcription and translation.

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